Analysis of outcomes in patients with supra-diaphragmatic vs infra-diaphragmatic diffuse large B cell lymphoma treated with R-CHOP therapy

被引：8

作者：

Nakajima, Yuki ^{[1
]}

Tomita, Naoto ^{[1
]}

Itabashi, Megumi ^{[2
]}

Miyashita, Kazuho ^{[3
]}

Watanabe, Reina ^{[4
]}

Miyazaki, Takuya ^{[1
]}

Tachibana, Takayoshi ^{[1
]}

Takasaki, Hirotaka ^{[4
]}

Kawasaki, Rika ^{[3
]}

Tanaka, Masatsugu ^{[2
]}

Hashimoto, Chizuko ^{[5
]}

Yamazaki, Etsuko ^{[1
]}

Taguchi, Jun ^{[6
]}

Fujimaki, Katsumichi ^{[3
]}

Sakai, Rika ^{[4
]}

Fujita, Hiroyuki ^{[6
]}

Fujisawa, Shin ^{[2
]}

Harano, Hiroshi ^{[7
]}

Motomura, Shigeki ^{[4
]}

Ishigatsubo, Yoshiaki ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Internal Med & Clin Immunol, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Med Ctr, Dept Hematol, Yokohama, Kanagawa 2360004, Japan

[3] Fujisawa City Hosp, Dept Hematol Immunol, Fujisawa, Kanagawa, Japan

[4] Kanagawa Canc Ctr, Dept Med Oncol, Yokohama, Kanagawa 2410815, Japan

[5] Yamato Municipal Hosp, Dept Hematol Oncol, Yamato, Japan

[6] Shizuoka Red Cross Hosp, Dept Hematol, Shizuoka, Japan

[7] Yokosuka City Hosp, Dept Hematol, Yokosuka, Kanagawa, Japan

来源：

LEUKEMIA RESEARCH | 2015年 / 39卷 / 02期

关键词：

Diffuse large B-cell lymphoma; Infra-diaphragmatic; Supra-diaphragmatic; Prognostic factor; Gastrointestinal involvement; EXTRANODAL INVOLVEMENT;

D O I：

10.1016/j.leukres.2014.11.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognostic implications of infra-diaphragmatic (InD) versus supra-diaphragmatic (SpD) primary lesions in limited-stage diffuse large B-cell lymphoma (DLBCL) remains unknown. This retrospective study aimed to assess the prognostic impact of spD and InD lesions as well as presence of gastrointestinal (GI) involvements in adults with limited-stage DLBCL. We analyzed data from 178 patients with limited-stage DLBCL who were treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone therapy at 7 institutions of the Yokohama City University Hematology Group between 2003 and 2009. The median age was 63 years (range, 18-80 years). The primary sites were SpD in 109 patients, and InD in 69. No statistical differences in progression-free survival (PFS) or overall survival (OS) were observed between patients with SpD lesions and those with InD lesions. However, when patients with SpD lesions, InD lesions with (n = 35), and without (n = 34) GI involvement were compared, the presence of GI lesions was associated with favorable PFS. The multivariate analysis revealed that SpD or InD localization had no independent effect on PFS or OS, whereas the presence of GI lesions was correlated with favorable PFS (P = 0.024, HR 0.09). (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：198 / 203

页数：6

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