Exploring the immunomodulatory and anticancer properties of zerumbone

被引:1
|
作者
Haque, Md. Areeful [1 ]
Jantan, Ibrahim [1 ]
Arshad, Laiba [1 ]
Bukhari, Syed Nasir Abbas [1 ]
机构
[1] Univ Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
关键词
TROPICAL GINGER SESQUITERPENE; BREAST-CANCER CELLS; NF-KAPPA-B; ZINGIBER-ZERUMBET; SUBTROPICAL GINGER; TRANSCRIPTION FACTORS; SIGNALING PATHWAYS; INDUCED APOPTOSIS; NATURAL-PRODUCTS; CYCLE ARREST;
D O I
10.1039/c7fo00595d
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Plant-derived immunomodulators and anti-cancer agents have attracted a lot of interest from natural product scientists for their efficacy and safety and their significant contribution towards understanding targeted drug action and drug delivery mechanisms. Zerumbone, the main constituent of Zingiber zerumbet rhizomes, has been investigated for its wide-spectrum role in treating multitargeted diseases. The rhizomes have been used as food flavoring agents in various cuisines and in herbal medicine. Many in vivo and in vitro studies have provided evidence of zerumbone as a potent immunomodulator as well as a potential anti-cancer agent. This review is an interesting compilation of all those significant outcomes from investigations carried out to date to explore the immunomodulatory and anticancer properties of zerumbone. The ultimate objective of this comprehensive review is to provide updated information and a critical assessment on zerumbone including its chemistry and immunomodulating and anticancer properties, which may be of paramount importance to provide a new path for ensuing research to discover new agents to treat cancers and immune-related diseases. In addition, updated information on the toxicology of zerumbone has also been summarized to provide its safety profile.
引用
收藏
页码:3410 / 3431
页数:22
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