Managing diabetes with nanomedicine: challenges and opportunities

被引：449
作者：
Veiseh, Omid [1 ,2 ,3 ]
Tang, Benjamin C. [2 ,3 ]
Whitehead, Kathryn A. [4 ]
Anderson, Daniel G. [1 ,2 ,3 ,5 ,6 ]
Langer, Robert [1 ,2 ,3 ,5 ,6 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
[2] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
[3] Boston Childrens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
[4] Carnegie Mellon Univ, Dept Chem Engn, Pittsburgh, PA 15213 USA
[5] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[6] MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2015年 / 14卷 / 01期
基金：
美国国家卫生研究院;
关键词：
BETA-CELL MASS; WALLED CARBON NANOTUBES; LARGE POROUS PARTICLES; LOOP INSULIN DELIVERY; DRUG-DELIVERY; BLOOD-GLUCOSE; GLYCEMIC CONTROL; INHALED INSULIN; IRON-OXIDE; MULTILAYER NANOENCAPSULATION;
D O I：
10.1038/nrd4477
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nanotechnology-based approaches hold substantial potential for improving the care of patients with diabetes. Nanoparticles are being developed as imaging contrast agents to assist in the early diagnosis of type 1 diabetes. Glucose nanosensors are being incorporated in implantable devices that enable more accurate and patient-friendly real-time tracking of blood glucose levels, and are also providing the basis for glucose-responsive nanoparticles that better mimic the body's physiological needs for insulin. Finally, nanotechnology is being used in non-invasive approaches to insulin delivery and to engineer more effective vaccine, cell and gene therapies for type 1 diabetes. Here, we analyse the current state of these approaches and discuss key issues for their translation to clinical practice.
引用
收藏
页码：45 / 57
页数：13
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