A guide to immunotherapy for COVID-19

被引：227

作者：

van de Veerdonk, Frank L. ^{[1
,2
]}

Giamarellos-Bourboulis, Evangelos ^{[3
]}

Pickkers, Peter ^{[4
,5
]}

Derde, Lennie ^{[6
]}

Leavis, Helen ^{[7
]}

van Crevel, Reinout ^{[1
,2
]}

Engel, Job J. ^{[1
,2
]}

Wiersinga, W. Joost ^{[8
]}

Vlaar, Alexander P. J. ^{[9
,10
]}

Shankar-Hari, Manu ^{[11
]}

van der Poll, Tom ^{[8
]}

Bonten, Marc ^{[12
]}

Angus, Derek C. ^{[13
,14
]}

van der Meer, Jos W. M. ^{[1
,2
]}

Netea, Mihai G. ^{[1
,2
,15
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands

[3] Univ Athens, Attikon Hosp, Dept Infect Dis, Athens, Greece

[4] Radboud Univ Nijmegen, Med Ctr, Dept Intens Care Med, Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands

[6] Univ Med Ctr Utrecht, Dept Intens Care, Utrecht, Netherlands

[7] Univ Med Ctr Utrecht, Dept Internal Med, Utrecht, Netherlands

[8] Univ Amsterdam, Amsterdam UMC, Ctr Expt Mol Med CEMM, Div Infect Dis, Amsterdam, Netherlands

[9] Univ Amsterdam, Amsterdam UMC, Dept Intens Care Med, Amsterdam, Netherlands

[10] Univ Amsterdam, Amsterdam UMC, Lab Expt Intens Care Med & Anesthesiol, Amsterdam, Netherlands

[11] Kings Coll London, Sch Immunobiol & Microbial Sci, London, England

[12] Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[13] UPMC, Pittsburgh, PA USA

[14] Univ Pittsburgh, Pittsburgh, PA USA

[15] Univ Bonn, Life & Med Sci Inst, Dept Immunol & Metab, Bonn, Germany

来源：

NATURE MEDICINE | 2022年 / 28卷 / 01期

关键词：

KINASE INHIBITORS; TISSUE FACTOR; OPEN-LABEL; MULTICENTER; NEUTROPHILS; THROMBOSIS; IMMUNITY; C5A;

D O I：

10.1038/s41591-021-01643-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This Review aims to support clinical decision-making by providing an overview of the evidence for immunotherapy strategies in patients with COVID-19. Immune dysregulation is an important component of the pathophysiology of COVID-19. A large body of literature has reported the effect of immune-based therapies in patients with COVID-19, with some remarkable successes such as the use of steroids or anti-cytokine therapies. However, challenges in clinical decision-making arise from the complexity of the disease phenotypes and patient heterogeneity, as well as the variable quality of evidence from immunotherapy studies. This Review aims to support clinical decision-making by providing an overview of the evidence generated by major clinical trials of host-directed therapy. We discuss patient stratification and propose an algorithm to guide the use of immunotherapy strategies in the clinic. This will not only help guide treatment decisions, but may also help to design future trials that investigate immunotherapy in other severe infections.

引用

页码：39 / 50

页数：12

共 104 条

[71] Patel J., RANDOMIZED TRIAL OTI, DOI [10.1101/2021.04.14.21255475(2021, DOI 10.1101/2021.04.14.21255475(2021]
[72] A Longitudinal Study of Immune Cells in Severe COVID-19 Patients
Payen, Didier
Cravat, Maxime
Maadadi, Hadil
Didelot, Carole
Prosic, Lydia
Dupuis, Claire
Losser, Marie-Reine
De Carvalho Bittencourt, Marcelo
[J]. FRONTIERS IN IMMUNOLOGY, 2020, 11
[73] Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort
Pouletty, Marie
Borocco, Charlotte
Ouldali, Naim
Caseris, Marion
Basmaci, Romain
Lachaume, Noemie
Bensaid, Philippe
Pichard, Samia
Kouider, Hanane
Morelle, Guillaume
Craiu, Irina
Pondarre, Corinne
Deho, Anna
Maroni, Arielle
Oualha, Mehdi
Amoura, Zahir
Haroche, Julien
Chommeloux, Juliette
Bajolle, Fanny
Beyler, Constance
Bonacorsi, Stephane
Carcelain, Guislaine
Kone-Paut, Isabelle
Bader-Meunier, Brigitte
Faye, Albert
Meinzer, Ulrich
Galeotti, Caroline
Melki, Isabelle
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (08) : 999 - 1006
[74] Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital
Ramcharan, Tristan
Nolan, Oscar
Lai, Chui Yi
Prabhu, Nanda
Krishnamurthy, Raghu
Richter, Alex G.
Jyothish, Deepthi
Kanthimathinathan, Hari Krishnan
Welch, Steven B.
Hackett, Scott
Al-Abadi, Eslam
Scholefield, Barnaby R.
Chikermane, Ashish
[J]. PEDIATRIC CARDIOLOGY, 2020, 41 (07) : 1391 - 1401
[75] Efficacy and safety of nintedanib in patients with advanced idiopathic pulmonary fibrosis
Richeldi, Luca
Kolb, Martin
Jouneau, Stephane
Wuyts, Wim A.
Schinzel, Birgit
Stowasser, Susanne
Quaresma, Manuel
Raghu, Ganesh
[J]. BMC PULMONARY MEDICINE, 2020, 20 (01)
[76] Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis
Richeldi, Luca
Costabel, Ulrich
Selman, Moises
Kim, Dong Soon
Hansell, David M.
Nicholson, Andrew G.
Brown, Kevin K.
Flaherty, Kevin R.
Noble, Paul W.
Raghu, Ganesh
Brun, Michele
Gupta, Abhya
Juhel, Nolwenn
Klueglich, Matthias
du Bois, Roland M.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (12) : 1079 - 1087
[77] Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience
Riollano-Cruz, Mariawy
Akkoyun, Esra
Briceno-Brito, Eudys
Kowalsky, Shanna
Reed, James
Posada, Roberto
Sordillo, Emilia Mia
Tosi, Michael
Trachtman, Rebecca
Paniz-Mondolfi, Alberto
[J]. JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (01) : 424 - 433
[78] A novel c5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways
Ritis, Konstantinos
Doumas, Michael
Mastellos, Dimitrios
Micheli, Anastasia
Giaglis, Stavros
Magotti, Paola
Rafail, Stavros
Kartalis, Georgios
Sideras, Paschalis
Lambris, John D.
[J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (07) : 4794 - 4802
[79] Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia
Rovina, Nikoletta
Akinosoglou, Karolina
Eugen-Olsen, Jesper
Hayek, Salim
Reiser, Jochen
Giamarellos-Bourboulis, Evangelos J.
[J]. CRITICAL CARE, 2020, 24 (01)
[80] Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm
Ruscitti, Piero
Berardicurti, Onorina
Di Benedetto, Paola
Cipriani, Paola
Iagnocco, Annamaria
Shoenfeld, Yehuda
Giacomelli, Roberto
[J]. FRONTIERS IN IMMUNOLOGY, 2020, 11

← 2 3 4 5 6 7 8 9 10 11 →