A guide to immunotherapy for COVID-19

被引：227

作者：

van de Veerdonk, Frank L. ^{[1
,2
]}

Giamarellos-Bourboulis, Evangelos ^{[3
]}

Pickkers, Peter ^{[4
,5
]}

Derde, Lennie ^{[6
]}

Leavis, Helen ^{[7
]}

van Crevel, Reinout ^{[1
,2
]}

Engel, Job J. ^{[1
,2
]}

Wiersinga, W. Joost ^{[8
]}

Vlaar, Alexander P. J. ^{[9
,10
]}

Shankar-Hari, Manu ^{[11
]}

van der Poll, Tom ^{[8
]}

Bonten, Marc ^{[12
]}

Angus, Derek C. ^{[13
,14
]}

van der Meer, Jos W. M. ^{[1
,2
]}

Netea, Mihai G. ^{[1
,2
,15
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands

[3] Univ Athens, Attikon Hosp, Dept Infect Dis, Athens, Greece

[4] Radboud Univ Nijmegen, Med Ctr, Dept Intens Care Med, Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands

[6] Univ Med Ctr Utrecht, Dept Intens Care, Utrecht, Netherlands

[7] Univ Med Ctr Utrecht, Dept Internal Med, Utrecht, Netherlands

[8] Univ Amsterdam, Amsterdam UMC, Ctr Expt Mol Med CEMM, Div Infect Dis, Amsterdam, Netherlands

[9] Univ Amsterdam, Amsterdam UMC, Dept Intens Care Med, Amsterdam, Netherlands

[10] Univ Amsterdam, Amsterdam UMC, Lab Expt Intens Care Med & Anesthesiol, Amsterdam, Netherlands

[11] Kings Coll London, Sch Immunobiol & Microbial Sci, London, England

[12] Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[13] UPMC, Pittsburgh, PA USA

[14] Univ Pittsburgh, Pittsburgh, PA USA

[15] Univ Bonn, Life & Med Sci Inst, Dept Immunol & Metab, Bonn, Germany

来源：

NATURE MEDICINE | 2022年 / 28卷 / 01期

关键词：

KINASE INHIBITORS; TISSUE FACTOR; OPEN-LABEL; MULTICENTER; NEUTROPHILS; THROMBOSIS; IMMUNITY; C5A;

D O I：

10.1038/s41591-021-01643-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This Review aims to support clinical decision-making by providing an overview of the evidence for immunotherapy strategies in patients with COVID-19. Immune dysregulation is an important component of the pathophysiology of COVID-19. A large body of literature has reported the effect of immune-based therapies in patients with COVID-19, with some remarkable successes such as the use of steroids or anti-cytokine therapies. However, challenges in clinical decision-making arise from the complexity of the disease phenotypes and patient heterogeneity, as well as the variable quality of evidence from immunotherapy studies. This Review aims to support clinical decision-making by providing an overview of the evidence generated by major clinical trials of host-directed therapy. We discuss patient stratification and propose an algorithm to guide the use of immunotherapy strategies in the clinic. This will not only help guide treatment decisions, but may also help to design future trials that investigate immunotherapy in other severe infections.

引用

页码：39 / 50

页数：12

共 104 条

[1] Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
Aiello, Anna
Farzaneh, Farzin
Candore, Giuseppina
Caruso, Calogero
Davinelli, Sergio
Gambino, Caterina Maria
Ligotti, Mattia Emanuela
Zareian, Nahid
Accardi, Giulia
[J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
[2] Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial
Aman, Jurjan
Duijvelaar, Erik
Botros, Liza
Kianzad, Azar
Schippers, Job R.
Smeele, Patrick J.
Azhang, Sara
Bartelink, Imke H.
Bayoumy, Ahmed A.
Bet, Pierre M.
Boersma, Wim
Bonta, Peter, I
Boomars, Karin A. T.
Bos, Lieuwe D. J.
Bragt, Job J. M. H. van
Braunstahl, Gert-Jan
Celant, Lucas R.
Eger, Katrien A. B.
Geelhoed, J. J. Miranda
Glabbeek, Yurika L. E. van
Grotjohan, Hans P.
Hagens, Laura A.
Happe, Chris M.
Hazes, Boaz D.
Heunks, Leo M. A.
Heuvel, Michel van den
Hoefsloot, Wouter
Hoek, Rianne J. A.
Hoekstra, Romke
Hofstee, Herman M. A.
Juffermans, Nicole P.
Kemper, E. Marleen
Kos, Renate
Kunst, Peter W. A.
Lammers, Ariana
Lee, Ivo van der
Lee, E. Laurien van der
Zee, Anke-Hilse Maitland-van der
Asam, Pearl F. M. Mau
Mieras, Adinda
Muller, Mirte
Neefjes, Elisabeth C. W.
Nossent, Esther J.
Oswald, Laurien M. A.
Overbeek, Maria J.
Pamplona, Carolina C.
Paternotte, Nienke
Pronk, Niels
Raaf, Michiel A. de
Raaij, Bas F. M. van
[J]. LANCET RESPIRATORY MEDICINE, 2021, 9 (09) : 957 - 968
[3] Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial
Angus, Derek C.
Derde, Lennie
Al-Beidh, Farah
Annane, Djillali
Arabi, Yaseen
Beane, Abigail
Van Bentum-Puijk, Wilma
Berry, Lindsay
Bhimani, Zahra
Bonten, Marc
Bradbury, Charlotte
Brunkhorst, Frank
Buxton, Meredith
Buzgau, Adrian
Cheng, Allen C.
de Jong, Menno
Detry, Michelle
Estcourt, Lise
Fitzgerald, Mark
Goossens, Herman
Green, Cameron
Haniffa, Rashan
Higgins, Alisa M.
Horvat, Christopher
Hullegie, Sebastiaan J.
Kruger, Peter
Lamontagne, Francois
Lawler, Patrick R.
Linstrum, Kelsey
Litton, Edward
Lorenzi, Elizabeth
Marshall, John
McAuley, Daniel
McGlothin, Anna
McGuinness, Shay
McVerry, Bryan
Montgomery, Stephanie
Mouncey, Paul
Murthy, Srinivas
Nichol, Alistair
Parke, Rachael
Parker, Jane
Rowan, Kathryn
Sanil, Ashish
Santos, Marlene
Saunders, Christina
Seymour, Christopher
Turner, Anne
van de Veerdonk, Frank
Venkatesh, Balasubramanian
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 324 (13): : 1317 - 1329
[4] Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI
Azam, Tariq U.
Shadid, Husam R.
Blakely, Pennelope
O'Hayer, Patrick
Berlin, Hanna
Pan, Michael
Zhao, Peiyao
Zhao, Lili
Pennathur, Subramaniam
Pop-Busui, Rodica
Altintas, Izzet
Tingleff, Jens
Stauning, Marius A.
Andersen, Ove
Adami, Maria-Evangelia
Solomonidi, Nicky
Tsilika, Maria
Tober-Lau, Pinkus
Arnaoutoglou, Eleni
Keitel, Verena
Tacke, Frank
Chalkias, Athanasios
Loosen, Sven H.
Giamarellos-Bourboulis, Evangelos J.
Eugen-Olsen, Jesper
Reiser, Jochen
Hayek, Salim S.
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 31 (11): : 2725 - 2735
[5] Multiple system inflammatory syndrome associated with SARS-CoV-2 infection in an adult and an adolescent
Bastug, Aliye
Aslaner, Halide
Aybar Bilir, Yesim
Kemirtlek, Nizamettin
Gursoy, Fahriye Melis
Bastug, Serdal
Bodur, Hurrem
[J]. RHEUMATOLOGY INTERNATIONAL, 2021, 41 (05) : 993 - 1008
[6] Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS
Bendib, Ines
Beldi-Ferchiou, Asma
Schlemmer, Frederic
Surenaud, Mathieu
Maitre, Bernard
Plonquet, Anne
Carteaux, Guillaume
Razazi, Keyvan
Godot, Veronique
Hue, Sophie
Mekontso Dessap, Armand
de Prost, Nicolas
[J]. CRITICAL CARE, 2021, 25 (01)
[7] Deployment of convalescent plasma for the prevention and treatment of COVID-19
Bloch, Evan M.
Shoham, Shmuel
Casadevall, Arturo
Sachals, Bruce S.
Shaz, Beth
Winters, Jeffrey L.
van Buskirk, Camille
Grossman, Brenda J.
Joyner, Michael
Henderson, Jeffrey P.
Pekosz, Andrew
Lau, Bryan
Wesolowski, Amy
Katz, Louis
Shan, Hua
Auwaerter, Paul G.
Thomas, David
Sullivan, David J.
Paneth, Nigel
Gehrie, Eric
Spitalnik, Steven
Hod, Eldad A.
Pollack, Lewis
Nicholson, Wayne T.
Pirofski, Liise-Anne
Bailey, Jeffrey A.
Tobian, Aaron A. R.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (06) : 2757 - 2765
[8] Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Bonaventura, Aldo
Vecchie, Alessandra
Dagna, Lorenzo
Martinod, Kimberly
Dixon, Dave L.
Van Tassell, Benjamin W.
Dentali, Francesco
Montecucco, Fabrizio
Massberg, Steffen
Levi, Marcel
Abbate, Antonio
[J]. NATURE REVIEWS IMMUNOLOGY, 2021, 21 (05) : 319 - 329
[9] Deciphering the state of immune silence in fatal COVID-19 patients
Bost, Pierre
De Sanctis, Francesco
Cane, Stefania
Ugel, Stefano
Donadello, Katia
Castellucci, Monica
Eyal, David
Fiore, Alessandra
Anselmi, Cristina
Barouni, Roza Maria
Trovato, Rosalinda
Caligola, Simone
Lamolinara, Alessia
Iezzi, Manuela
Facciotti, Federica
Mazzariol, Annarita
Gibellini, Davide
De Nardo, Pasquale
Tacconelli, Evelina
Gottin, Leonardo
Polati, Enrico
Schwikowski, Benno
Amit, Ido
Bronte, Vincenzo
[J]. NATURE COMMUNICATIONS, 2021, 12 (01)
[10] The role of IgG Fc receptors in antibody-dependent enhancement
Bournazos, Stylianos
Gupta, Aaron
Ravetch, Jeffrey, V
[J]. NATURE REVIEWS IMMUNOLOGY, 2020, 20 (10) : 633 - 643

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