Immunocytokines for cancer treatment: past, present and future

被引：95
作者：
Neri, Dario [1 ]
Sondel, Paul M. [2 ,3 ,4 ,5 ]
机构：
[1] ETH, Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Vladimir Prelog Weg 4, CH-8093 Zurich, Switzerland
[2] Univ Wisconsin, Dept Pediat, Madison, WI 53706 USA
[3] Univ Wisconsin, Dept Human Oncol, Madison, WI 53706 USA
[4] Univ Wisconsin, Dept Genet, Madison, WI 53706 USA
[5] Univ Wisconsin, UW Carbone Canc Ctr, Madison, WI 53706 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2016年 / 40卷
基金：
美国国家卫生研究院; 瑞士国家科学基金会;
关键词：
TUMOR-TARGETING PROPERTIES; CYTOKINE FUSION PROTEINS; ANTIBODY-BASED DELIVERY; ANTITUMOR-ACTIVITY; MEDIATED DELIVERY; MELANOMA PATIENTS; DOSE-ESCALATION; SOLID TUMORS; STAGE-III; T-CELLS;
D O I：
10.1016/j.coi.2016.03.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunocytokines are antibody-cytokine fusion proteins, with the potential to preferentially localize on tumor lesions and to activate anticancer immunity at the site of disease. Various tumor targets (e.g., cell membrane antigens and extracellular matrix components) and antibody formats (e.g., intact IgG and antibody fragments) have been considered for immunocytokine development and some products have advanced to clinical trials. In this review, we present relevant concepts and strategies for the design and use of anticancer immunocytokine products. In addition, we discuss emerging strategies for the pharmaceutical development and clinical application of this promising class of biopharmaceuticals.
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页码：96 / 102
页数：7
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