Physically microstriped-nanoengineered polystyrene surface (PMS-NPS) for regulating cell attachment and alignment fabricated by nano-injection molding

被引：6

作者：

Cha, Kyoung Je ^{[1
]}

Lim, Jiwon ^{[2
]}

Na, Moon-Hee ^{[2
]}

Kim, Dong Sung ^{[2
]}

机构：

[1] Korea Inst Ind Technol KITECH, Ultimate Mfg Technol Grp, 320 Techno Sunhwan Ro, Daegu 711880, South Korea

[2] Pohang Univ Sci & Technol POSTECH, Dept Mech Engn, 77 Cheongam Ro, Pohang 790784, Gyungbuk, South Korea

来源：

MICROELECTRONIC ENGINEERING | 2016年 / 158卷

基金：

新加坡国家研究基金会;

关键词：

Cell attachment; Cell alignment; Nano-injection molding; Nano-mold insert; Physically microstriped-nanoengineered polystyrene surface; DIFFERENTIATION; LITHOGRAPHY; TOPOGRAPHY; POLYMERS; MICRO;

D O I：

10.1016/j.mee.2016.02.034

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

In the present study, we developed a physically microstriped-nanoengineered polystyrene surface (PMS-NPS) to control cell attachment and alignment. The PMS-NPS was mass replicated by nano-injection molding with a rigid metallic nano-mold insert, which was cost-effectively manufactured by two-step anodization process, UV-photolithography, and electroforming process. In our previous result, attachment of MG-63 cells was found to be enhanced on the nanoengineered polystyrene surface (NPS) without any biochemical treatments. In this study, the PMS-NPS was proposed to control the cell attachment and alignment by biophysical cue without biochemical cue. Throughout this study, we were able to observe the enhanced MG-63 cell attachment and alignment on PMS-NPS compared to flat PS. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：11 / 15

页数：5

共 18 条

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