Self-Assembly of Short Collagen-Related Peptides into Fibrils via Cation-π Interactions

被引：47

作者：

Chen, Chia-Ching ^{[1
]}

Hsu, Wei ^{[1
]}

Kao, Tang-Chun ^{[1
]}

Horng, Jia-Cherng ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

BIOCHEMISTRY | 2011年 / 50卷 / 13期

关键词：

TRIPLE-HELICAL PEPTIDES; HIGHER-ORDER STRUCTURES; DESIGNED PEPTIDES; ASSOCIATION; STABILITY; RECOGNITION; BIOLOGY; GELS;

D O I：

10.1021/bi1018573

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Introduction of a cationic residue at the N-terminus and an aromatic residue at the C-terminus of a collagen-related peptide can generate favorable cation-pi interactions between the termini of collagen triple helices. The experimental results indicate that such cation-pi interactions can promote the self-assembly of collagen triple helices into a higher-order structure in a head-to-tail manner. Our current work shows that cation-pi interactions can serve as an effective force in preparing collagen-related biomaterials.

引用

页码：2381 / 2383

页数：3

共 29 条

[1] Molecular structure of the collagen triple helix [J].

Brodsky, B ;

Persikov, AV .

FIBROUS PROTEINS: COILED-COILS, COLLAGEN AND ELASTOMERS, 2005, 70 :301-+

[2] Triple-helical peptides: An approach to collagen conformation, stability, and self-association [J].

Brodsky, Barbara ;

Thiagarajan, Geetha ;

Madhan, Balaraman ;

Kar, Karunakar .

BIOPOLYMERS, 2008, 89 (05) :345-353

[3] Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions [J].

Cejas, Mabel A. ;

Kinnney, William A. ;

Chen, Cailin ;

Vinter, Jeremy G. ;

Almond, Harold R. ;

Balss, Karin M. ;

Maryanoff, Cynthia A. ;

Schmidt, Ute ;

Breslav, Michael ;

Mahan, Andrew ;

Lacy, Eilyn ;

Maryanoff, Bruce E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (25) :8513-8518

[4] Collagen-related peptides: Self-assembly of short, single strands into a functional biomaterial of micrometer scale [J].

Cejas, Mabel A. ;

Kinney, William A. ;

Chen, Cailin ;

Leo, Gregory C. ;

Tounge, Brett A. ;

Vinter, Jeremy G. ;

Joshi, Pratik P. ;

Maryanoff, Bruce E. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (08) :2202-+

[5] Contributions of cation-π interactions to the collagen triple helix stability [J].

Chen, Chia-Ching ;

Hsu, Wei ;

Hwang, Kuo-Chu ;

Hwu, Jih Ru ;

Lin, Chun-Cheng ;

Horng, Jia-Cherng .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2011, 508 (01) :46-53

[6] Cation-pi interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp [J].

Dougherty, DA .

SCIENCE, 1996, 271 (5246) :163-168

[7] Cation-π interactions in structural biology [J].

Gallivan, JP ;

Dougherty, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9459-9464

[8] Interruptions in the collagen repeating tripeptide pattern can promote supramolecular association [J].

Hwang, Eileen S. ;

Thiagarajan, Geetha ;

Parmar, Avanish S. ;

Brodsky, Barbara .

PROTEIN SCIENCE, 2010, 19 (05) :1053-1064

[9] Self-association of collagen triple helix peptides into higher order structures [J].

Kar, Karunakar ;

Amin, Priyal ;

Bryan, Michael A. ;

Persikov, Anton V. ;

Mohs, Angela ;

Wang, Yuh-Hwa ;

Brodsky, Barbara .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (44) :33283-33290

[10] Aromatic Interactions Promote Self-Association of Collagen Triple-Helical Peptides to Higher-Order Structures [J].

Kar, Karunakar ;

Ibrar, Sajjad ;

Nanda, Vikas ;

Getz, Todd M. ;

Kunapuli, Satya P. ;

Brodsky, Barbara .

BIOCHEMISTRY, 2009, 48 (33) :7959-7968

← 1 2 3 →