Insulin-mediated blood flow and glucose uptake

被引：0

作者：

Floras, JS

Meneilly, G

机构：

[1] Univ Toronto, Toronto, ON, Canada

[2] Univ Toronto, Mt Sinai Hosp, Hlth Network, Toronto, ON M5G 1X5, Canada

[3] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2001年 / 17卷

关键词：

aging; blood flow; endothelium; glucose; insulin; nitric oxide;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Normal aging is characterized by resistance to insulin-mediated vasodilation and glucose uptake. The mechanism or mechanisms responsible for resistance to the actions of insulin remain unclear. The majority of insulin-mediated glucose uptake occurs in skeletal muscle. Ii: has recently been demonstrated that insulin increases skeletal muscle blood flow via an endothelium-derived, nitric oxide dependent mechanism. The authors' investigations of the relation between skeletal muscle blood flow and insulin-mediated glucose uptake in healthy elderly and young subjects are reviewed.

引用

页码：7A / 10A

页数：4

共 7 条

[1]

ANDRES R, 1966, AUTOMAT ANAL CHEM, P486

[2]

Baron AD, 1996, J INVEST MED, V44, P406

[3] Role of blood flow in the regulation of muscle glucose uptake [J].