Effect of Interleukin-1β on Lipid Peroxidation in Emotiogenic Structures of the Brain in Rats during Acute Stress

被引：5

作者：

Pertsov, S. S. ^{[1
]}

Koplik, E. V. ^{[1
]}

Kalinichenko, L. S. ^{[1
]}

Simbirtsev, A. S. ^{[2
]}

机构：

[1] Russian Acad Sci, PK Anokhin Inst Normal Physiol, Moscow 117901, Russia

[2] Fed Med & Biol Agcy Russia, State Res Inst Highly Pure Biopreparat, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 150卷 / 01期

关键词：

interleukin-1; beta; emotional stress; lipid peroxidation; brain; active and passive rats;

D O I：

10.1007/s10517-010-1054-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effects of immunomodulatory cytokine interleukin-1 beta on lipid peroxidation in emotiogenic structures of the brain (hypothalamus, sensorimotor cortex, and amygdala) of behaviorally active and passive rats with different prognostic resistance to stress. Immobilization of animals with simultaneous electrocutaneous stimulation (1 h) served as the model of acute emotional stress. Intraperitoneal injection of IL-1 beta (5 mu g/kg) was followed by accumulation of malonic dialdehyde (end-product of lipid peroxidation) in all structures of the brain in passive rats, as well as in the hypothalamus of active animals. As differentiated from active rats, stress exposure in passive specimens was accompanied by a selective increase in malonic dialdehyde content in the sensorimotor cortex and amygdala. Pretreatment with IL-1 beta prevented activation of lipid peroxidation in the studied structures of the brain in passive rats after stress exposure. Our results show the specific effect of IL-1 beta on free-radical processes in the hypothalamus, sensorimotor cortex, and amygdala in rats with various behavioral parameters. Regional features of lipid peroxidation in emotiogenic structures of the brain in animals with different emotional reactivity probably contribute to the existence of significant variations in the individual resistance to emotional stress.

引用

页码：9 / 12

页数：4

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