Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer

被引：0
|
作者：
Bogolyubova, Apollinariya, V [1 ]
Pachuashvili, Nano, V [2 ]
Tkachuk, Arina, V [3 ]
Mokrysheva, Natalia G. [3 ]
Urusova, Liliya S. [3 ]
机构：
[1] Natl Res Ctr Hematol, Moscow 125167, Russia
[2] IM Sechenov First Moscow State Med Univ, Inst Clin Morphol & Digital Pathol, Moscow 119991, Russia
[3] Endocrinol Res Ctr, Moscow 117036, Russia
来源：
CANCERS | 2022年 / 14卷 / 21期
关键词：
tumor microenvironment; tumor-infiltrated immune cells; histological variant; adrenocortical cancer; oncocytic adrenocortical cancer; HELSINKI SCORE; CARCINOMA; MICROENVIRONMENT;
D O I：
10.3390/cancers14215303
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The analysis of the tumor microenvironment, especially tumor-infiltrated immune cells, is essential for predicting tumor prognosis, clinical outcomes, and therapy strategies. Adrenocortical cancer is a rare nonimmunogenic malignancy in which the importance of the presence of immune cells is not well understood. In our study, we made the first attempt to understand the interplay between the histology of adrenocortical cancer and its immune landscape using cases from The Cancer Genome Atlas database and the Endocrinology Research Centre collection (Moscow, Russia). We showed that the oncocytic variant of adrenocortical cancer is characterized by intensive immune infiltration and better survival, and it is crucial to analyze the effect of immune infiltration independently for each histological variant.
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页数：10
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