Adipocyte-fatty acid binding protein and non-alcoholic fatty liver disease in the elderly

被引：11

作者：

Masetti, Marco ^{[1
]}

Bianchi, Giampaolo ^{[1
]}

Gianotti, Giordano ^{[1
]}

Giovagnoli, Marco ^{[1
]}

Vizioli, Luca ^{[1
]}

Zorzi, Veronica ^{[1
]}

Rossi, Valentina ^{[1
]}

Forti, Paola ^{[1
]}

Zoli, Marco ^{[1
]}

机构：

[1] Univ Bologna, Dept Med & Surg Sci, S Orsola Malpighi Hosp, I-40138 Bologna, Italy

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2014年 / 26卷 / 03期

关键词：

Metabolic syndrome; Metaflammation; Non-alcoholic fatty liver disease; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; AP2; ASSOCIATION; EXPRESSION;

D O I：

10.1007/s40520-013-0156-0

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background Adipocyte-fatty acid binding protein (A-FABP) is an intracellular lipid transporter that mediates metabolically triggered inflammation, and it is associated with insulin resistance, atherogenic dyslipidemia, and cardiovascular risk. Aims The aim of this study was to evaluate A-FABP behavior in elderly people, and especially its association with liver steatosis at abdominal ultrasound. Method Cross-sectional study of two cohort of individuals with and without steatosis, with assessment of several clinical and laboratory variables. Prospective evaluation of liver steatosis remodeling after six years of follow-up. One hundred and fifty-six subjects aged over 65 years were enrolled. Results Serum A-FABP positively correlated with body fat percentage, total cholesterol, serum triglycerides and erythrocyte sedimentation rate. Unlike expected, high A-FABP levels were associated with absence of liver steatosis, while there was no evidence of association with steatosis grade changes after 6 years of follow-up. Conclusion Among individuals aging more than 65 years included in the study, A-FABP was inversely associated with liver steatosis. It can be argued, that still uncovered mechanisms modify A-FABP behavior in elderly people, especially its association with multifactorial diseases.

引用

页码：241 / 247

页数：7

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