Relation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillation

被引：347

作者：

Psychari, SN

Apostolou, TS

Sinos, L

Hamodraka, E

Liakos, G

Kremastinos, DT

机构：

[1] Onassis Cardiac Surg Ctr, Dept Cardiol 2, Athens 17674, Greece

[2] Nikea Gen Hosp, Dept Cardiol 2, Athens, Greece

[3] Nikea Gen Hosp, Dept Biochem, Athens, Greece

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 95卷 / 06期

关键词：

D O I：

10.1016/j.amjcard.2004.11.032

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies have demonstrated inflammation to be a risk factor in patients with atrial fibrillation (AF). In this prospective study of 90 patients with persistent and permanent AF and 46 controls, we found increased C-reactive protein (CRP) and interleukin-6 levels in patients-with AF compared with controls (p < 0.001). Multivariate analysis revealed CRP to be an independent predictor of AF (p = 0.01). Left atrial diameter was positively related to CRP and interleukin-6 (p < 0.001, R = 0.37; p < 0.001, R = 0.46, respectively) and negatively related to left ventricular function. Interleukin-6 levels were positively related to AF duration before cardioversion (p = 0.02). Elevation of CRP and interleukin-6 suggest a role of inflammation in AF, and the relation of CRP and interleukin-6 to left atrial size and AF duration before cardioversion indicates that inflammation may participate in the process of atrial remodeling. (c) 2005 by Excerpta Medica Inc.

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页码：764 / 767

页数：4

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