Microparticles: Key Protagonists in Cardiovascular Disorders

被引：120

作者：

Amabile, Nicolas ^{[1
,3
]}

Rautou, Pierre-Emmanuel ^{[1
]}

Tedgui, Alain ^{[1
,2
]}

Boulanger, Chantal M. ^{[1
,2
]}

机构：

[1] 1 INSERM, Paris Cardiovasc Res Ctr PARCC, U970, F-75015 Paris, France

[2] Univ Paris 05, UMR S970, Paris, France

[3] Marie Lannelongue Ctr, Dept Cardiol, Le Plessis Robinson, France

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2010年 / 36卷 / 08期

关键词：

Microparticles; endothelial dysfunction; inflammation; coagulation; angiogenesis; CIRCULATING ENDOTHELIAL MICROPARTICLES; HUMAN ATHEROSCLEROTIC PLAQUES; TYPE-2; DIABETES-MELLITUS; PLATELET-DERIVED MICROPARTICLES; SHED MEMBRANE MICROPARTICLES; TISSUE FACTOR EXPRESSION; ACUTE CORONARY SYNDROMES; ANGIOGENESIS IN-VITRO; STAGE RENAL-DISEASE; PROCOAGULANT MICROPARTICLES;

D O I：

10.1055/s-0030-1267044

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Microparticles (MP) are shed membrane vesicles released by various cell types following apoptosis or activation. MP circulate in human plasma and also accumulate in atherosclerotic lesions. A growing body of evidence has highlighted their involvement in inflammation, angiogenesis, coagulation, and the regulation of vascular tone. MP may therefore contribute to the initiation and development of atherosclerosis and its complications. Plasma MP originate from platelets, leukocytes, erythrocytes, and endothelial cells, and their levels increase in patients with cardiovascular diseases; specific cardiovascular medications also affect plasma MP levels. Most recent data suggest a potential prognostic role of circulating MP for identification of subjects prone to develop cardiovascular complications.

引用

页码：907 / 916

页数：10

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