Rhabdomyolysis caused by the moderate CYP3A4 inhibitor fluconazole in a patient on stable atorvastatin therapy: a case report and literature review

被引：12

作者：

Hsiao, S. -H. ^{[1
]}

Chang, H. -J. ^{[1
]}

Hsieh, T. -H. ^{[2
]}

Kao, S. -M. ^{[1
]}

Yeh, P. -Y. ^{[1
]}

Wu, T. -J. ^{[3
,4
]}

机构：

[1] Natl Cheng Kung Univ Hosp, Dept Pharm, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Dept Internal Med, Med Coll & Hosp, Tainan, Taiwan

[3] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Tainan, Taiwan

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2016年 / 41卷 / 05期

关键词：

atorvastatin; drug interaction; fluconazole; rhabdomyolysis; FUSIDIC ACID; SIMVASTATIN; STATIN; SAFETY; AMIODARONE;

D O I：

10.1111/jcpt.12425

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objectiveRhabdomyolysis is a severe potential adverse drug reaction of statin therapy. We report a case of rhabdomyolysis due to drug-drug interaction (DDI) between atorvastatin and fluconazole and review the literature. Case summaryA 70-year-old woman received atorvastatin for hyperlipidaemia without any problem for 4 years. When intravenous fluconazole was added for treating a fungal infection, rhabdomyolysis developed 2 weeks later. Removal of atorvastatin led to the resolution of her rhabdomyolysis. What is new and conclusionOur case demonstrates that in some subjects even a moderate CYP3A4 inhibitor such as fluconazole may lead to rhabdomyolysis in subjects receiving a statin. Characteristics of reported cases of rhabdomyolysis associated with drug interaction between statins and fluconazole.

引用

页码：575 / 578

页数：4

共 50 条

[21] Telbivudine-induced rhabdomyolysis in a patient undergoing haemodialysis: A case report and review of literature
Wu, Keping
Xu, Xiaochang
Huang, Leidan
Zhu, Enyi
Dong, Yejing
Zhang, Zhijuan
Yan, Xiuhong
Zhang, Yimin
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2023, 51 (12)
[22] Trimethoprim-sulfamethoxazole associated rhabdomyolysis in a patient with AIDS: Case report and review of the literature
Walker, Steven
Norwood, John
Thornton, Camille
Schaberg, Dennis
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2006, 331 (06) : 339 - 341
[23] Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism: A rare case report and literature review
Wang, Dawei
Wang, Yanqiu
MEDICINE, 2018, 97 (14)
[24] Rhabdomyolysis in an HIV-infected patient following coronary angiography: case report and literature review
Sbrana, Francesco
Coceani, Michele
Iapoce, Riccardo
Petersen, Christina
Rovai, Daniele
INTERNATIONAL JOURNAL OF STD & AIDS, 2014, 25 (06) : 452 - 454
[25] Suspected Levetiracetam-Induced Acute Rhabdomyolysis in a Patient With Retinoblastoma: A Case Report and Literature Review
Alshehabi, Khadija M.
Askandarani, Sumayah
Alkhalifah, Zainab A.
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (05)
[26] Atorvastatin associated with gamma glutamyl transpeptidase elevation in a hyperlipidemia patient A case report and literature review
Xu, Yan
Wu, Yanqing
MEDICINE, 2020, 99 (40)
[27] Brivaracetam-Associated Rhabdomyolysis Requiring Renal Replacement Therapy: A Case Report and Review of the Literature
Alok, Khaled
Lin, Amanda
Dematteo, Celine Rahman
Abrar, Husain
Levy, Zachary
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (04)
[28] Primary empty sella syndrome-caused rhabdomyolysis misdiagnosed as recurrent sepsis: a case report and literature review
Yu, Dongxu
Shi, Leilei
Zhang, Xinrui
Yang, Huifen
Feng, Jing
Wang, Yubao
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2023, 130 : 144 - 146
[29] PD-1 Inhibitor Therapy in a Patient with Preexisting P-ANCA Vasculitis: A Case Report and Review of the Literature
Ramos, Amanda
del Carmen, Marcela
Yeku, Oladapo
CASE REPORTS IN ONCOLOGICAL MEDICINE, 2020, 2020
[30] Case report and literature review: Acute rhabdomyolysis caused by overheating of electric blanket complicated with Guillain-Barré syndrome
Jiang, Dongyang
Zhao, Ming
Li, Xiaojun
Hu, Qiongdan
Zhang, Qiong
FRONTIERS IN NEUROLOGY, 2024, 15

← 1 2 3 4 5 →