Construction of a prognosis-predicting model based on autophagy-related genes for hepatocellular carcinoma (HCC) patients

被引：12

作者：

Zhu, Yayun ^{[1
]}

Wang, Ru ^{[2
,3
]}

Chen, Wanbin ^{[4
]}

Chen, Qiuyu ^{[5
]}

Zhou, Jian ^{[6
,7
,8
,9
,10
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai, Peoples R China

[2] Johns Hopkins Univ, Inst Cell Engn, Sch Med, Baltimore, MD 21205 USA

[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Breast Surg, Xian, Shaanxi, Peoples R China

[4] Johns Hopkins Univ, Dept Mkt, Carey Business Sch, Baltimore, MD 21202 USA

[5] Fudan Univ, Dept Clin Immunol, Childrens Hosp, Shanghai, Peoples R China

[6] Fudan Univ, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai, Peoples R China

[7] Fudan Univ, State Key Lab Genet Engn, Shanghai, Peoples R China

[8] Fudan Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Shanghai, Peoples R China

[9] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China

[10] Fudan Univ, Zhongshan Hosp, Shanghai Key Lab Organ Transplantat, Shanghai, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 14期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

autophagy-related genes; prognosis; hepatocellular carcinoma; The Cancer Genome Atlas; TARGETING AUTOPHAGY; INDUCED APOPTOSIS; POOR-PROGNOSIS; CANCER; INHIBITION; RHEB; PROLIFERATION; TUMORIGENESIS; ACTIVATION; THERAPY;

D O I：

10.18632/aging.103507

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background: Autophagy, a highly conserved cellular catabolic process by which the eukaryotic cells deliver autophagosomes engulfing cellular proteins and organelles to lysosomes for degradation, is critical for maintaining cellular homeostasis in response to various signals and nutrient stresses. The dysregulation of autophagy has been noted in the pathogenesis of cancers. Our study aims to investigate the prognosis-predicting value of autophagy-related genes (ARG) in hepatocellular carcinoma (HCC). Results: The signature was constructed based on eight ARGs, which stratified HCC patients into high- and low-risk groups in terms of overall survival (OS) (Hazard Ratio, HR=4.641, 95% Confidential Interval, CI, 3.365-5.917, P=0.000). The ARG signature is an independent prognostic indicator for HCC patients (HR = 1.286, 95% CI, 1.194-1.385; P < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for 5-year survival is 0.765. Conclusion: This study provides a potential prognostic signature for predicting the prognosis of HCC patients and molecular insights into the significance of autophagy in HCC. Methods: Sixty-two differentially expressed ARGs and the clinical characteristics and basic information of the 369 enrolled HCC patients were retrieved from The Cancer Genome Atlas (TCGA) database. the Cox proportional hazard regression analysis was adopted to identify survival-related ARGs, based on which a prognosis predicting signature was constructed.

引用

页码：14582 / 14592

页数：11