Anti-inflammatory flavagline glycosides and putrescine bisamides from Aglaia perviridis leaves

被引：5
作者：
An, Fa-Liang [2 ]
Xu, Wen-Jun [2 ]
Yang, Ming-Hua [2 ]
Luo, Jun [1 ,2 ]
Kong, Ling-Yi [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, Jiangsu Key Lab Bioact Nat Prod Res, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China
来源：
TETRAHEDRON | 2020年 / 76卷 / 25期
关键词：
Flavagline; Aglaia perviridis; Anti-inflammatory; ECD calculation;
D O I：
10.1016/j.tet.2020.131257
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new cyclopenta[b]benzopyran glycosides (1-4), aglapervirisins J-M, two new putrescine bisamides (6-7), aglaiamides M - N, and a pair of novel flavagline enantiomer (+/-) aglapernin (8) were isolated from the leaves of A. perviridis. Their structures were elucidated based on comprehensive analysis of spectroscopic methods. The anti-inflammatory activities of those compounds were evaluated as inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cell lines. Cyclopenta[b]benzopyran glycosides (1-4) showed weak nitric oxide inhibitory activity with IC50 values ranging from 29.5 to 43.6 mu M, and the putrescine bisamides (5-7) exhibited potent nitric oxide inhibitory activity with IC50 values ranging from 7.4 to 19.5 mu M. (C) 2020 Published by Elsevier Ltd.
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页数：6
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