Anterior cingulate activation relates to local cortical thickness

被引:20
作者
Hegarty, Catherine E.
Foland-Ross, Lara C. [1 ]
Narr, Katherine L.
Townsend, Jennifer D.
Bookheimer, Susan Y.
Thompson, Paul M.
Altshuler, Lori L. [2 ]
机构
[1] Stanford Univ, Dept Psychol, Mood & Anxiety Disorders Lab, Stanford, CA 94305 USA
[2] VA Greater Los Angeles Healthcare Syst, W Los Angeles Healthcare Ctr, Dept Psychiat, Los Angeles, CA USA
关键词
anterior cingulate cortex; cortical thickness; functional magnetic resonance imaging; response inhibition; RESPONSE-INHIBITION; BRAIN; CORTEX; ROBUST;
D O I
10.1097/WNR.0b013e3283525a95
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Few studies have examined the relationship between local anatomic thickness of the cortex and the activation signals arising from it. Using structural and functional MRI, we examined whether a relationship exists between cortical thickness and brain activation. Twenty-eight participants were asked to perform the Go/NoGo response inhibition task known to activate the anterior cingulate and the prefrontal cortex. Structural data of the same regions were simultaneously collected. We hypothesized that cortical thickness in these brain regions would positively correlate with brain activation. Data from the structural MRI were aligned with those of functional MRI activation. There was a positive linear correlation between cortical thickness and activation during response inhibition in the right anterior cingulate cortex (Brodmann's Area 24). No significant thickness-activation correlations were found in the prefrontal cortex. Correlations between cortical thickness and activation may occur only in certain brain regions. NeuroReport 23:420-424 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:420 / 424
页数:5
相关论文
共 23 条
[1]  
[Anonymous], 2008, Principles of cognitive neuroscience
[2]   Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition [J].
Aron, Adam R. ;
Durston, Sarah ;
Eagle, Dawn M. ;
Logan, Gordon D. ;
Stinear, Cathy M. ;
Stuphorn, Veit .
JOURNAL OF NEUROSCIENCE, 2007, 27 (44) :11860-11864
[3]   The neural basis of inhibition in cognitive control [J].
Aron, Adam R. .
NEUROSCIENTIST, 2007, 13 (03) :214-228
[4]   Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease [J].
Braskie, Meredith N. ;
Klunder, Andrea D. ;
Hayashi, Kiralee M. ;
Protas, Hillary ;
Kepe, Vladimir ;
Miller, Karen J. ;
Huang, S. -C. ;
Barrio, Jorge R. ;
Ercoli, Linda M. ;
Siddarth, Prabha ;
Satyamurthy, Nagichettiar ;
Liu, Jie ;
Toga, Arthur W. ;
Bookheimer, Susan Y. ;
Small, Gary W. ;
Thompson, Paul M. .
NEUROBIOLOGY OF AGING, 2010, 31 (10) :1669-1678
[5]   Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania [J].
Foland, Lara C. ;
Altshuler, Lori L. ;
Bookheimer, Susan Y. ;
Eisenberger, Naomi ;
Townsend, Jennifer ;
Thompson, Paul M. .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2008, 162 (01) :27-37
[6]   Function and structure of the right inferior frontal cortex predict individual differences in response inhibition: A model-based approach [J].
Forstmann, Birte U. ;
Jahfari, Sara ;
Scholte, H. Steven ;
Wolfensteller, Uta ;
van den Wildenberg, Wery P. M. ;
Ridderinkhof, K. Richard .
JOURNAL OF NEUROSCIENCE, 2008, 28 (39) :9790-9796
[7]   Response inhibition and impulsivity: an fMRI study [J].
Horn, NR ;
Dolan, M ;
Elliott, R ;
Deakin, JFW ;
Woodruff, PWR .
NEUROPSYCHOLOGIA, 2003, 41 (14) :1959-1966
[8]   Improved optimization for the robust and accurate linear registration and motion correction of brain images [J].
Jenkinson, M ;
Bannister, P ;
Brady, M ;
Smith, S .
NEUROIMAGE, 2002, 17 (02) :825-841
[9]   Relationships between Brain Activation and Brain Structure in Normally Developing Children [J].
Lu, Lisa H. ;
Dapretto, Mirella ;
O'Hare, Elizabeth D. ;
Kan, Eric ;
McCourt, Sarah T. ;
Thompson, Paul M. ;
Toga, Arthur W. ;
Bookheimer, Susan Y. ;
Sowell, Elizabeth R. .
CEREBRAL CORTEX, 2009, 19 (11) :2595-2604
[10]  
MacDonald D, 1998, THESIS MCGILL U MONT