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Curcumin and Graphene Oxide Incorporated into Alginate Hydrogels as Versatile Devices for the Local Treatment of Squamous Cell Carcinoma
被引:16
作者:
Madeo, Lorenzo Francesco
[1
]
Sarogni, Patrizia
[2
]
Cirillo, Giuseppe
[3
]
Vittorio, Orazio
[4
,5
,6
]
Voliani, Valerio
[2
]
Curcio, Manuela
[3
]
Shai-Hee, Tyler
[4
,5
,6
]
Buechner, Bernd
[1
,7
]
Mertig, Michael
[8
,9
]
Hampel, Silke
[1
]
机构:
[1] Leibniz Inst Solid State & Mat Res Dresden, D-01069 Dresden, Germany
[2] Ist Italiano Tecnol, Ctr Nanotechnol Innovat, Piazza San Silvestro 12, I-56127 Pisa, Italy
[3] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy
[4] Univ New South Wales, Lowy Canc Res Ctr, Childrens Canc Inst, High St, Randwick, NSW 2052, Australia
[5] Univ New South Wales, Sch Womens & Childrens Hlth, Kensington, NSW 2052, Australia
[6] Univ New South Wales, Australian Ctr NanoMed, ARC Ctr Excellence Convergent Bionano Sci & Techn, Kensington, NSW 2052, Australia
[7] Tech Univ Dresden, Inst Solid State & Mat Phys, D-01062 Dresden, Germany
[8] Tech Univ Dresden, Inst Phys Chem, D-01062 Dresden, Germany
[9] Kurt Schwabe Inst Mess & Sensortech Meinsberg eV, D-04736 Waldheim, Germany
来源:
关键词:
curcumin;
graphene oxide;
alginate hydrogels;
hybrid hydrogels;
ionic crosslinking;
squamous cell carcinoma;
IN-VITRO;
ENCAPSULATED CURCUMIN;
CONTROLLED-RELEASE;
SUPPRESSES GROWTH;
HEAD;
MICROPARTICLES;
DESIGN;
BEADS;
D O I:
10.3390/ma15051648
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
With the aim of preparing hybrid hydrogels suitable for use as patches for the local treatment of squamous cell carcinoma (SCC)-affected areas, curcumin (CUR) was loaded onto graphene oxide (GO) nanosheets, which were then blended into an alginate hydrogel that was crosslinked by means of calcium ions. The homogeneous incorporation of GO within the polymer network, which was confirmed through morphological investigations, improved the stability of the hybrid system compared to blank hydrogels. The weight loss in the 100-170 degrees C temperature range was reduced from 30% to 20%, and the degradation of alginate chains shifted to higher temperatures. Moreover, GO enhanced the stability in water media by counteracting the de-crosslinking process of the polymer network. Cell viability assays showed that the loading of CUR (2.5% and 5% by weight) was able to reduce the intrinsic toxicity of GO towards healthy cells, while higher amounts were ineffective due to the antioxidant/prooxidant paradox. Interestingly, the CUR-loaded systems were found to possess a strong cytotoxic effect in SCC cancer cells, and the sustained CUR release (~50% after 96 h) allowed long-term anticancer efficiency to be hypothesized.
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页数:15
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