A facile one-pot synthesis of chiral β-amino esters

被引：64

作者：

Bunlaksananusorn, T ^{[1
]}

Rampf, F ^{[1
]}

机构：

[1] Lanxess Deutsch GmbH, Fine Chem Res & Dev, D-51369 Leverkusen, Germany

来源：

SYNLETT | 2005年 / 17期

关键词：

reductive amination; beta-amino esters; beta-keto esters; Ru-ClMeOBIPHEP catalyst;

D O I：

10.1055/s-2005-917108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a facile one-pot synthesis of chiral beta-amino esters via direct reductive amination of beta-keto esters with ammonium acetate (NH4OAc) and H-2 in the presence of chiral Ru-CIMeOBIPHEP catalysts using 2,2,2-trifluoroethanol (TFE) as a solvent, leading to beta-amino esters in high yields with high enantioselectivities (up to 99% ee).

引用

页码：2682 / 2684

页数：3

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