Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships

被引:0
作者
Zarghi, Afshin [1 ]
Arfaei, Sara [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tehran, Iran
来源
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2011年 / 10卷 / 04期
关键词
NSAIDs; Cyclooxygenase; Selective COX-2 Inhibitors; Coxibs; SAR; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENDOPEROXIDE-H SYNTHASE-1; CYCLOOXYGENASE-2; INHIBITORS; BIOLOGICAL EVALUATION; INDUCIBLE CYCLOOXYGENASE; CRYSTAL-STRUCTURE; DESIGN; DERIVATIVES; EXPRESSION; POTENT;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the undesired side effects arise from inhibition of COX-1 activity. Thus, it was though that more selective COX-2 inhibitors would have reduced side effects. Based upon a number of selective COX-2 inhibitors (rofecoxib, celecoxib, valdecoxib etc.) were developed as safer NSAIDs with improved gastric safety profile. However, the recent market removal of some COXIBs such as rofecoxib due to its adverse cardiovascular side effects clearly encourages the researchers to explore and evaluate alternative templates with COX-2 inhibitory activity. Recognition of new avenues for selective COX-2 inhibitors in cancer chemotherapy and neurological diseases such as Parkinson and Alzheimer's diseases still continues to attract investigations on the development of COX-2 inhibitors. This review highlights the various structural classes of selective COX-2 inhibitors with special emphasis on their structure-activity relationships.
引用
收藏
页码:655 / 683
页数:29
相关论文
共 50 条
[41]   The role of COX-2 in acute pain and the use of selective COX-2 inhibitors for acute pain relief [J].
Lee, Y ;
Rodriguez, C ;
Dionne, RA .
CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (14) :1737-1755
[42]   Chondroprotective Actions of Selective COX-2 Inhibitors In Vivo: A Systematic Review [J].
Timur, Ufuk Tan ;
Caron, Marjolein M. J. ;
Jeuken, Ralph M. ;
Bastiaansen-Jenniskens, Yvonne M. ;
Welting, Tim J. M. ;
van Rhijn, Lodewijk W. ;
van Osch, Gerjo J. V. M. ;
Emans, Pieter J. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (18) :1-15
[43]   Selective COX-2 Inhibitors: Road from Success to Controversy and the Quest for Repurposing [J].
El-Malah, Afaf A. ;
Gineinah, Magdy M. ;
Deb, Pran Kishore ;
Khayyat, Ahdab N. ;
Bansal, Monika ;
Venugopala, Katharigatta N. ;
Aljahdali, Anfal S. .
PHARMACEUTICALS, 2022, 15 (07)
[44]   Clinical pharmacology of selective COX-2 inhibitors [J].
Capone, ML ;
Tacconelli, S ;
Sciulli, MG ;
Patrignani, P .
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2003, 16 (02) :49-58
[45]   Synthesis and biological evaluation of resveratrol amide derivatives as selective COX-2 inhibitors [J].
Xin, Min ;
Wu, Haoyu ;
Du, Yuan ;
Liu, Sheng ;
Zhao, Feng ;
Mou, Xiaofeng .
CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 380
[46]   Structure-activity relationships of Wee1 inhibitors: A review [J].
Du, Xingkai ;
Li, Jian ;
Luo, Xiaojiao ;
Li, Rong ;
Li, Feng ;
Zhang, Yiwen ;
Shi, Jianyou ;
He, Jun .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 203
[47]   Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors [J].
Badrey, Mohamed G. ;
Abdel-Aziz, Hassan M. ;
Gomha, Sobhi M. ;
Abdalla, Mohamed M. ;
Mayhoub, Abdelrahman S. .
MOLECULES, 2015, 20 (08) :15287-15303
[48]   Pyrimidine-based fluorescent COX-2 inhibitors: synthesis and biological evaluation [J].
Tietz, Ole ;
Kaur, Jatinder ;
Bhardwaj, Atul ;
Wuest, Frank R. .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (30) :7250-7257
[49]   Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update [J].
Cui, Jiahua ;
Jia, Jinping .
CURRENT MEDICINAL CHEMISTRY, 2021, 28 (18) :3622-3646
[50]   Synthesis of novel pyrazolyl tetrazoles as selective COX-2 inhibitors [J].
Swetha, Kolli Sri ;
Parameshwar, Ravula ;
Reddy, B. Madhava ;
Babu, V. Harinadha .
MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (10) :4886-4892