miR-155: A Novel Target in Allergic Asthma

被引：58

作者：

Zhou, Hong ^{[1
]}

Li, Junyao ^{[1
]}

Gao, Peng ^{[1
]}

Wang, Qi ^{[1
]}

Zhang, Jie ^{[1
]}

机构：

[1] Jilin Univ, Affiliated Hosp 2, Dept Resp Med, Changchun 130041, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 10期

关键词：

miR-155; allergic disease; asthma; immune response; glucocorticoid; B-CELL LYMPHOMAS; CD4(+) T-CELLS; AIRWAY INFLAMMATION; IN-VIVO; AUTOIMMUNE INFLAMMATION; DENDRITIC CELLS; IMMUNE FUNCTION; MOUSE MODEL; MICRORNA-155; EXPRESSION;

D O I：

10.3390/ijms17101773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs), a class of small non-coding RNAs of 18-24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of immune responses and oncogenesis. Previous studies have identified miR-155 as a crucial positive regulator of Th1 immune response in autoimmune diseases, but as a suppressor of Th2 immunity in allergic disorders. However, recent studies have found new evidence that miR-155 plays an indispensible role in allergic asthma. This review summarizes the recent findings with respect to miR-155 in immune responses and the underlying mechanisms responsible for miR-155-related allergic diseases, as well as the similarities between miR-155 and glucocorticoids in immunity.

引用

页数：11

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