Correlation of the modified Medical Research Council dyspnea scale with airway structure assessed by three-dimensional CT in patients with chronic obstructive pulmonary disease

被引：13

作者：

Yasui, Hideki ^{[1
]}

Inui, Naoki ^{[1
,2
]}

Karayama, Masato ^{[1
]}

Mori, Kazutaka ^{[1
]}

Hozumi, Hironao ^{[1
]}

Suzuki, Yuzo ^{[1
]}

Furuhashi, Kazuki ^{[1
]}

Enomoto, Noriyuki ^{[1
]}

Fujisawa, Tomoyuki ^{[1
]}

Nakamura, Yutaro ^{[1
]}

Watanabe, Hiroshi ^{[2
]}

Suda, Takafumi ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Internal Med, Div 2, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

[2] Hamamatsu Univ Sch Med, Dept Clin Pharmacol & Therapeut, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

来源：

RESPIRATORY MEDICINE | 2019年 / 146卷

基金：

日本学术振兴会;

关键词：

Chronic obstructive pulmonary disease; Dyspnea; Modified medical research council dyspnea scale; Three-dimensional computed tomography; GLOBAL STRATEGY; HEALTH-STATUS; COPD; EMPHYSEMA; EXACERBATION; DISABILITY; PREVENTION; MANAGEMENT; DIAGNOSIS; BURDEN;

D O I：

10.1016/j.rmed.2018.11.020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Dyspnea is a common symptom in chronic obstructive pulmonary disease (COPD). The modified Medical Research Council (mMRC) dyspnea scale is a widely used questionnaire to assess dyspnea. However, the relationship of the mMRC dyspnea scale with morphological airway structures in COPD remains unclear. We evaluated the correlation between the mMRC dyspnea scale and imaging-based airway structures in patients with COPD. Methods: The wall area (WA) and airway inner luminal area (Ai) of third- to sixth-generation bronchi and the percentage of low attenuation area with less than-950 HU (% LAA) of the lungs were measured using three-dimensional computed tomography in patients with COPD. WA and Ai were corrected by body surface area (BSA). Results: Forty-two clinically stable patients with COPD were enrolled. The median (range) mMRC dyspnea scale was 2 (0-3). The mMRC dyspnea scale score was significantly correlated with WA/BSA of fifth-and sixth-generation bronchi (Spearman correlation coefficient rho = 0.386, rho = 0.012;.= 0.484, rho = 0.001, respectively). Partial rank correlation analysis showed that the mMRC dyspnea scale score was significantly correlated with WA/BSA of sixth-generation bronchi, independent of the confounding factors of age, body mass index, % predicted forced expiratory volume in 1 s, % LAA, and Ai/BSA (rho=0.481, p=0.003). However, the % LAA and Ai/BSA were not correlated with this dyspnea scale. Conclusion: Bronchial WA assessed by three-dimensional computed tomography may be used as an assessment tool for dyspnea in patients with COPD.

引用

页码：76 / 80

页数：5

共 39 条

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