Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii

被引：37

作者：

Kennedy, George M. ^{[1
]}

Morisaki, J. Hiroshi ^{[2
]}

Champion, Patricia A. DiGiuseppe ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA

[2] Univ Calif San Francisco, Program Microbial Pathogenesis & Host Def, San Francisco, CA 94143 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2012年 / 78卷 / 06期

基金：

美国国家科学基金会;

关键词：

FREE-LIVING AMEBAS; INFECTION; VIRULENCE; SECRETION; DICTYOSTELIUM; TUBERCULOSIS; BACTERIA; INVASION; SYSTEM;

D O I：

10.1128/AEM.06965-11

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum. We demonstrate that the ESX-1 secretion system is required for M. marinum pathogenesis and that M. marinum utilizes actin-based motility in amoebae. Therefore, at least two virulence pathways used by M. marinum in macrophages are conserved during M. marinum infection of amoebae.

引用

页码：2049 / 2052

页数：4

共 28 条

[21] Mycobacterium marinum:: the generalization and specialization of a pathogenic mycobacterium [J].

Stamm, LA ;

Brown, EJ .

MICROBES AND INFECTION, 2004, 6 (15) :1418-1428

[22] Role of the WASP family proteins for Mycobacterium marinum actin tail formation [J].

Stamm, LM ;

Pak, MA ;

Morisaki, JH ;

Snapper, SB ;

Rottner, K ;

Lommel, S ;

Brown, EJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (41) :14837-14842

[23] Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility [J].

Stamm, LM ;

Morisaki, JH ;

Gao, LY ;

Jeng, RL ;

McDonald, KL ;

Roth, R ;

Takeshita, S ;

Heuser, J ;

Welch, MD ;

Brown, EJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (09) :1361-1368

[24] Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system [J].

Stanley, SA ;

Raghavan, S ;

Hwang, WW ;

Cox, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (22) :13001-13006

[25] Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component [J].

Stoop, Esther J. M. ;

Schipper, Tim ;

Huber, Sietske K. Rosendahl ;

Nezhinsky, Alexander E. ;

Verbeek, Fons J. ;

Gurcha, Sudagar S. ;

Besra, Gurdyal S. ;

Vandenbroucke-Grauls, Christina M. J. E. ;

Bitter, Wilbert ;

van der Sar, Astrid M. .

DISEASE MODELS & MECHANISMS, 2011, 4 (04) :526-536

[26] Biodiversity of amoebae and amoeba-resisting bacteria in a hospital water network [J].

Thomas, V ;

Herrera-Rimann, K ;

Blanc, DS ;

Greub, G .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (04) :2428-2438

[27] Tuberculous granuloma formation is enhanced by a Mycobacterium virulence determinant [J].

Volkman, HE ;

Clay, H ;

Beery, D ;

Chang, JCW ;

Sherman, DR ;

Ramakrishnan, L .

PLOS BIOLOGY, 2004, 2 (11) :1946-1956

[28] Evidence that hsp90 is involved in the altered interactions of Acanthamoeba castellanii variants with bacteria [J].

Yan, L ;

Cerny, RL ;

Cirillo, JD .

EUKARYOTIC CELL, 2004, 3 (03) :567-578

← 1 2 3 →