Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii

被引：37
作者：
Kennedy, George M. [1 ]
Morisaki, J. Hiroshi [2 ]
Champion, Patricia A. DiGiuseppe [1 ]
机构：
[1] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA
[2] Univ Calif San Francisco, Program Microbial Pathogenesis & Host Def, San Francisco, CA 94143 USA
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2012年 / 78卷 / 06期
基金：
美国国家科学基金会;
关键词：
FREE-LIVING AMEBAS; INFECTION; VIRULENCE; SECRETION; DICTYOSTELIUM; TUBERCULOSIS; BACTERIA; INVASION; SYSTEM;
D O I：
10.1128/AEM.06965-11
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum. We demonstrate that the ESX-1 secretion system is required for M. marinum pathogenesis and that M. marinum utilizes actin-based motility in amoebae. Therefore, at least two virulence pathways used by M. marinum in macrophages are conserved during M. marinum infection of amoebae.
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收藏
页码：2049 / 2052
页数：4
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