Antibiotic resistance is ancient: implications for drug discovery

被引：101

作者：

Wright, Gerard D. ^{[1
]}

Poinar, Hendrik ^{[2
]}

机构：

[1] McMaster Univ, MG DeGroote Inst Infect Dis Res, Dept Biochem & Biomed Sci, Hamilton, ON L8S 4K1, Canada

[2] McMaster Univ, McMaster Ancient DNA Ctr, Dept Anthropol, Hamilton, ON L8S 4L9, Canada

来源：

TRENDS IN MICROBIOLOGY | 2012年 / 20卷 / 04期

关键词：

antibiotic; ancient DNA; vancomycin; beta-lactamase; tetracycline; aminoglycoside; COMBINATIONS; RESISTOME;

D O I：

10.1016/j.tim.2012.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An unfailing observation over the past 70 years is that resistance to all antibiotics emerges eventually after use in the clinic. Where does this resistance come from? Recent work has shown that antibiotic resistance genes are common in metagenomes of ancient sediments. This prevalence of resistance, well before the use of antibiotics, denotes the importance of taking microbial chemical ecology and deep metagenomic profiling into account in the development and use of antibiotics.

引用

页码：157 / 159

页数：3

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