Epstein- Barr Virus and Cancer

被引：375

作者：

Farrell, Paul J. ^{[1
]}

机构：

[1] Imperial Coll, Fac Med, Virol Sect, London W2 1PG, England

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 14 | 2019年 / 14卷

基金：

英国医学研究理事会;

关键词：

EBNA; LMP; miRNA; lymphoma; nasopharyngeal carcinoma; gastric carcinoma; B-CELL LYMPHOMA; EPHRIN RECEPTOR A2; INFECTS T-CELLS; ANTIGEN; EBNA1; TUMOR-SUPPRESSOR; EBV INFECTION; NASOPHARYNGEAL CARCINOMA; CONTROLLED-TRIAL; GENE-EXPRESSION; IMMUNE EVASION;

D O I：

10.1146/annurev-pathmechdis-012418-013023

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Epstein-Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide, and viral genes are expressed in the malignant cells. EBV also very efficiently causes the proliferation of infected human B lymphocytes. The functions of the viral proteins and small RNAs that may contribute to EBV-associated cancers are becoming increasingly clear, and a broader understanding of the sequence variation of the virus genome has helped to interpret their roles. The improved understanding of the mechanisms of these cancers means that there are great opportunities for the early diagnosis of treatable stages of EBV-associated cancers and the use of immunotherapy to target EBV-infected cells or overcome immune evasion. There is also scope for preventing disease by immunization and for developing therapeutic agents that target the EBV gene products expressed in the cancers.

引用

页码：29 / 53

页数：25

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