Clonidine immediately after immobilization stress prevents long-lasting locomotion reduction in the rat

被引:17
|
作者
Shinba, T [1 ]
Shinozaki, T [1 ]
Mugishima, G [1 ]
机构
[1] Tokyo Inst Psychiat, Dept Neurophysiol, Setagaya Ku, Tokyo 1568585, Japan
来源
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2001年 / 25卷 / 08期
关键词
anxiety; clonidine; immobilization stress; locomotion reduction; noradrenaline; post-traumatic stress disorder;
D O I
10.1016/S0278-5846(01)00203-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. Stress-induced behavioral change in the rat has been utilized as an animal model of anxiety disorder. The authors examined the effect of early intervention by noradrenergic inhibition on stress-induced long-lasting locomotion reduction. 2. Clonidine, an alpha2 agonist, was administered immediately after a single session of 8 min immobilization stress in a restraining box, followed by locomotion measurement on day 1, day 7, and day 14 after the stress session. 3. In the saline-treated control group, locomotion on day 1, day 7, and day 14 after the 8 min stress session was significantly reduced to about 80 % in comparison with that before the stress. This finding confirmed the previous report that a single stressful event could lead to long-lasting behavioral changes. When clonidine was administered, locomotion reduction was not observed on any post-stress day. 4. The results suggest that early intervention by noradrenergic inhibition to stressful events may have a preventive effect on subsequent behavioral change which may be considered as an animal model of post-traumatic stress disorder.
引用
收藏
页码:1629 / 1640
页数:12
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