CuI-catalyzed hydroxylation of aryl bromides under the assistance of 5-bromo-2-(1H-imidazol-2-yl)pyridine and related ligands

被引：34
作者：
Jia, Jianhuan [1 ]
Jiang, Chenglin [1 ]
Zhang, Xiaojing [1 ]
Jiang, Yongwen [2 ]
Ma, Dawei [2 ]
机构：
[1] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 43期
基金：
中国国家自然科学基金;
关键词：
SUBSTITUTED PHENOLS; COUPLING REACTIONS; ETHER FORMATION; DIARYL ETHERS; C-N; HALIDES; DERIVATIVES; HYDROXIDE; MILD; ARYLATION;
D O I：
10.1016/j.tetlet.2011.08.059
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A number of substituted 2-pyridin-2-yl-1H-benzoimidazoles and 2-(1H-imidazol-2-yl)pyridines were screened for promoting CuI-catalyzed hydroxylation of aryl bromides, which led to the discovery of the combination of Cut and 5-bromo-2-(1H-imidazol-2-yl)pyridine as an effective catalytic system for this transformation. Both electron-rich and electronic-deficient aryl bromides could be converted into the corresponding substituted phenols in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5593 / 5595
页数：3
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