P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth

被引：47
|
作者：
He, Hong [1 ]
Nhi Huynh [1 ]
Liu, Kevin H. [1 ]
Malcontenti-Wilson, Cathy [1 ]
Zhu, Jin [2 ,3 ]
Christophi, Christopher [1 ]
Shulkes, Arthur [1 ]
Baldwin, Graham S. [1 ]
机构：
[1] Univ Melbourne, Dept Surg, Austin Hlth, Melbourne, Vic 3084, Australia
[2] Third Mil Med Univ, Southwest Hosp, Chongqing 400038, Peoples R China
[3] Third Mil Med Univ, Inst Hepatobiliary Surg, Chongqing 400038, Peoples R China
来源：
CANCER LETTERS | 2012年 / 317卷 / 01期
基金：
英国医学研究理事会;
关键词：
PAK1; beta-Catenin; CRC; P21-ACTIVATED KINASES; COLON-CANCER; MUTATIONS; RAS; APC; PROGRESSION; METASTASIS; PROTEIN; KRAS; WNT;
D O I：
10.1016/j.canlet.2011.11.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The p21-activated kinase 1 (PAK1) plays important roles in cell growth, motility, and transformation. The aims of this study were to delineate the signalling mechanisms downstream of PAK1, and to investigate the importance of PAK1 for colorectal cancer (CRC) growth and metastasis in vivo. PAK1 knockdown in human CRC cell lines inhibited beta-catenin expression, beta-catenin/TCF4 transcriptional activity, and the expression of c-Myc. In mouse models PAK1 knockdown suppressed the growth and metastasis of human CRC cells by decreasing proliferation and increasing apoptosis. Our findings demonstrate for the first time the crucial role of PAK1 in CRC progression in vivo. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：65 / 71
页数：7
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