Novel alleles at the HLA-DRB1 and-DQB1 loci

被引：14
|
作者：
Lazaro, A. M. [1 ]
Xiao, Y. [1 ]
Masaberg, C. [1 ]
Lebeck, L. [2 ]
Ng, J. [1 ]
Hurley, C. K. [1 ]
Posch, P. E. [1 ]
机构：
[1] Georgetown Univ, Med Ctr, CW Bill Young Marrow Donor Res & Recruitment Prog, Dept Oncol & Pediat, Washington, DC 20057 USA
[2] Univ Calif San Diego, Dept Immunogenet & Transplantat, San Diego, CA 92103 USA
来源：
TISSUE ANTIGENS | 2008年 / 72卷 / 01期
关键词：
DNA sequencing; human leukocyte antigen (HLA)-DRB1; HLA-DQB1;
D O I：
10.1111/j.1399-0039.2008.01070.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Twelve novel human leukocyte antigen class II alleles are described; eight DRB1 alleles and four DQB1 alleles. Nine of the variants are single nucleotide substitutions from their most homologous allele, of which six result in amino acid changes (DRB1*0459, *1156 and *1522; DQB1*0205, *0320 and *0321) and three are silent substitutions (DRB1*030105 and *040304, and DQB1*030104). The remaining alleles (DRB1*0906, *1464 and *1468) differ from their most similar alleles by two to three nucleotide substitutions which alter one to two amino acids.
引用
收藏
页码：72 / 74
页数：3
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