Studies toward the synthesis of natural and unnatural dienediynes 1. Approaches to a functionalised bicyclic ring system

被引：48

作者：

Caddick, S ^{[1
]}

Delisser, VM

Doyle, VE

Khan, S

Avent, AG

Vile, S

机构：

[1] Univ Sussex, Chem Lab, Ctr Biomol Design & Drug Dev, Brighton BN1 9QJ, E Sussex, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

aldol reactions; cyclisation; diynes;

D O I：

10.1016/S0040-4020(99)00045-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a functionalised bicyclic ring system related to the naturally occurring dienediynes, NCS and Kedarcidin Chromophores is presented. Key steps involve: conjugate addition of an enediyne to a functionalised enone and intramolecular boron mediated aldol reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2737 / 2754

页数：18

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