Immunopathogenesis of vitiligo

被引：120

作者：

Sandoval-Cruz, Manuel ^{[1
,2
]}

Garcia-Carrasco, Mario ^{[3
,4
]}

Sanchez-Porras, Renan ^{[4
]}

Mendoza-Pinto, Claudia ^{[4
]}

Jimenez-Hernandez, Mario ^{[4
]}

Munguia-Realpozo, Pamela ^{[4
]}

Ruiz-Argueelles, Alejandro ^{[5
]}

机构：

[1] IMSS, HGR 36, Dept Dermatol, Puebla, Mexico

[2] IMSS, HGR 36, CMN Manuel Avila Camacho, Dept Internal Med, Puebla, Mexico

[3] Benemerita Univ Autonoma Puebla, Dept Immunol & Rheumatol, Puebla, Mexico

[4] IMSS, HGR 36, Syst Autoimmune Dis Res Unit, Puebla, Mexico

[5] Labs Clin Puebla, Puebla, Mexico

来源：

AUTOIMMUNITY REVIEWS | 2011年 / 10卷 / 12期

关键词：

Autoimmunity; Melanocyte; Pathogenesis; Vitiligo; NON-SEGMENTAL VITILIGO; T-CELLS; AUTOIMMUNE VITILIGO; MONONUCLEAR-CELLS; ACTIVE VITILIGO; HLA-DR; SKIN; MELANOCYTES; PATHOGENESIS; EXPRESSION;

D O I：

10.1016/j.autrev.2011.02.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of vitiligo. Cellular and humoral immunities have been implicated in the development of vitiligo and their role continues to be investigated. Peripheral blood and skin biopsies of patients with vitiligo show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of vitiligo or only a consequence. (C) 2011 Published by Elsevier B.V.

引用

页码：762 / 765

页数：4

共 42 条

[1] Current remedies for vitiligo
Abu Tahir, M.
Pramod, K.
Ansari, S. H.
Ali, Laved
[J]. AUTOIMMUNITY REVIEWS, 2010, 9 (07) : 516 - 520
[2] ABNORMAL EXPRESSION OF MHC CLASS-II AND ICAM-1 BY MELANOCYTES IN VITILIGO
ALBADRI, AMT
FOULIS, AK
TODD, PM
GARIOCH, JJ
GUDGEON, JE
STEWART, DG
GRACIE, JA
GOUDIE, RB
[J]. JOURNAL OF PATHOLOGY, 1993, 169 (02) : 203 - 206
[3] Ali R, 2010, PAK J PHARM SCI, V23, P97
[4] Evaluation of activatory and inhibitory natural killer cell receptors in non-segmental vitiligo: a flow cytometric study
Basak, P. Y.
Adiloglu, A. K.
Koc, I. G.
Tas, T.
Akkaya, V. B.
[J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2008, 22 (08) : 970 - 976
[5] The role of helper and regulatory T cells in the pathogenesis of vitiligo
Basak, Pinar Y.
Adiloglu, Ali K.
Ceyhan, Ali Murat
Tas, Tekin
Akkaya, Vahide B.
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 60 (02) : 256 - 260
[6] CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent
Gattinoni, Luca
Ranganathan, Anju
Surman, Deborah R.
Palmer, Douglas C.
Antony, Paul A.
Theoret, Marc R.
Heimann, David M.
Rosenberg, Steven A.
Restifo, Nicholas P.
[J]. BLOOD, 2006, 108 (12) : 3818 - 3823
[7] Mapping of melanin-concentrating hormone receptor 1 B cell epitopes predicts two major binding sites for vitiligo patient autoantibodies
Gavalas, Nikos G.
Gottumukkala, Raju V. S. R. K.
Gawkrodger, David J.
Watson, Philip F.
Weetman, Anthony P.
Kemp, E. Helen
[J]. EXPERIMENTAL DERMATOLOGY, 2009, 18 (05) : 454 - 463
[8] T-CELL PROFILES IN VITILIGO
GRIMES, PE
GHONEUM, M
STOCKTON, T
PAYNE, C
KELLY, AP
ALFRED, L
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1986, 14 (02) : 196 - 201
[9] Vitiligo: Pathogenetic Hypotheses and Targets for Current Therapies
Guerra, Liliana
Dellambra, Elena
Brescia, Serena
Raskovic, Desanka
[J]. CURRENT DRUG METABOLISM, 2010, 11 (05) : 451 - 467
[10] Vitiligo Update
Halder, Rebat M.
Chappell, Johnathan L.
[J]. SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 2009, 28 (02) : 86 - 92

← 1 2 3 4 5 →