Immunopathogenesis of vitiligo

被引：122

作者：

Sandoval-Cruz, Manuel ^{[1
,2
]}

Garcia-Carrasco, Mario ^{[3
,4
]}

Sanchez-Porras, Renan ^{[4
]}

Mendoza-Pinto, Claudia ^{[4
]}

Jimenez-Hernandez, Mario ^{[4
]}

Munguia-Realpozo, Pamela ^{[4
]}

Ruiz-Argueelles, Alejandro ^{[5
]}

机构：

[1] IMSS, HGR 36, Dept Dermatol, Puebla, Mexico

[2] IMSS, HGR 36, CMN Manuel Avila Camacho, Dept Internal Med, Puebla, Mexico

[3] Benemerita Univ Autonoma Puebla, Dept Immunol & Rheumatol, Puebla, Mexico

[4] IMSS, HGR 36, Syst Autoimmune Dis Res Unit, Puebla, Mexico

[5] Labs Clin Puebla, Puebla, Mexico

来源：

AUTOIMMUNITY REVIEWS | 2011年 / 10卷 / 12期

关键词：

Autoimmunity; Melanocyte; Pathogenesis; Vitiligo; NON-SEGMENTAL VITILIGO; T-CELLS; AUTOIMMUNE VITILIGO; MONONUCLEAR-CELLS; ACTIVE VITILIGO; HLA-DR; SKIN; MELANOCYTES; PATHOGENESIS; EXPRESSION;

D O I：

10.1016/j.autrev.2011.02.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of vitiligo. Cellular and humoral immunities have been implicated in the development of vitiligo and their role continues to be investigated. Peripheral blood and skin biopsies of patients with vitiligo show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of vitiligo or only a consequence. (C) 2011 Published by Elsevier B.V.

引用

页码：762 / 765

页数：4

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