Origins and activity of the Mediator complex

被引：88

作者：

Conaway, Ronald C. ^{[1
,2
]}

Conaway, Joan Weliky ^{[1
,2
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2011年 / 22卷 / 07期

关键词：

Mediator; RNA polymerase II; Transcription; RNA-POLYMERASE-II; TRANSCRIPTION-ELONGATION IMPAIRMENT; HORMONE RECEPTOR FUNCTION; SACCHAROMYCES-CEREVISIAE; MAMMALIAN MEDIATOR; BINDING PROTEIN; GENE-EXPRESSION; YEAST MEDIATOR; NUCLEAR RECEPTORS; COFACTOR COMPLEX;

D O I：

10.1016/j.semcdb.2011.07.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：729 / 734

页数：6

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