Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation

被引:12
作者
Ito, Hisakatsu [1 ]
Tsuneki, Hiroshi [2 ]
Sasaoka, Toshiyasu [2 ]
Toyooka, Naoki [3 ]
Matsuo, Mitsuhiro [1 ]
Yamazaki, Mitsuaki [1 ]
机构
[1] Univ Toyama, Dept Anesthesiol, Toyama, Japan
[2] Univ Toyama, Dept Clin Pharmacol, Toyama, Japan
[3] Univ Toyama, Fac Engn, Toyama, Japan
关键词
NORADRENERGIC NEURONS; BENZODIAZEPINES; EPIDEMIOLOGY; DISTURBANCE; INSOMNIA; SYSTEM; DRUGS;
D O I
10.1371/journal.pone.0264386
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Both chronic pain and sleep disorders are associated with a reduction in the quality of life. They can be both a cause and a consequence of each other, and should therefore be simultaneously treated. However, optimal treatments for chronic pain-related sleep disorders are not well established. Here, we aimed to investigate the effects of suvorexant, a novel sleep drug, and mirtazapine, a noradrenergic and specific serotonergic antidepressant, on painrelated changes in sleep parameters in a preclinical chronic pain mice model, by partial sciatic nerve ligation. We evaluated the quantity, duration, and depth of sleep by analyzing the electroencephalogram and voluntary activity by counting the number of wheel rotations to determine various symptoms of sleep disorders, including reduced total sleep time, fragmentation, low quality, and impaired activity in the daytime. Suvorexant and mirtazapine normalized the reduction in sleep time and fragmented sleep, further regaining the sleep depth at sleep onset in the chronic pain state in nerve-ligated mice. Mirtazapine also increased the percentage of rapid eye movement sleep in mice. Suvorexant decreased voluntary activity, which was prolonged after administration; however, mirtazapine did not decrease it. Although the effects of suvorexant and mirtazapine on sleep and activity are different, both suvorexant and mirtazapine could be potential therapeutic agents for chronic pain-related sleep disorders.
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页数:14
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