Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation
Both chronic pain and sleep disorders are associated with a reduction in the quality of life. They can be both a cause and a consequence of each other, and should therefore be simultaneously treated. However, optimal treatments for chronic pain-related sleep disorders are not well established. Here, we aimed to investigate the effects of suvorexant, a novel sleep drug, and mirtazapine, a noradrenergic and specific serotonergic antidepressant, on painrelated changes in sleep parameters in a preclinical chronic pain mice model, by partial sciatic nerve ligation. We evaluated the quantity, duration, and depth of sleep by analyzing the electroencephalogram and voluntary activity by counting the number of wheel rotations to determine various symptoms of sleep disorders, including reduced total sleep time, fragmentation, low quality, and impaired activity in the daytime. Suvorexant and mirtazapine normalized the reduction in sleep time and fragmented sleep, further regaining the sleep depth at sleep onset in the chronic pain state in nerve-ligated mice. Mirtazapine also increased the percentage of rapid eye movement sleep in mice. Suvorexant decreased voluntary activity, which was prolonged after administration; however, mirtazapine did not decrease it. Although the effects of suvorexant and mirtazapine on sleep and activity are different, both suvorexant and mirtazapine could be potential therapeutic agents for chronic pain-related sleep disorders.
机构:
Univ Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
Alsaadi, Saad M.
;
McAuley, James H.
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Neurosci Res Australia, Sydney, NSW, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
McAuley, James H.
;
Hush, Julia M.
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Univ Sydney, Fac Hlth Sci, Sydney, NSW 2050, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
Hush, Julia M.
;
Maher, Chris G.
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h-index: 0
机构:
Univ Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
机构:
Univ Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Alvarenga Dias, Rejane Camila
;
Kulak Junior, Jaime
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h-index: 0
机构:
Univ Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Kulak Junior, Jaime
;
Ferreira da Costa, Eloise Haydee
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h-index: 0
机构:
Evangel Mackenzie Univ, Dept Med, R Padre Agostinho 2770, BR-80730000 Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Ferreira da Costa, Eloise Haydee
;
Nisihara, Renato Mitsunori
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Evangel Mackenzie Univ, Dept Med, R Padre Agostinho 2770, BR-80730000 Curitiba, Parana, Brazil
Positivo Univ, Dept Med, Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
机构:
Thomas Jefferson Univ, Sidney Kimmel Med Coll, Jefferson Sleep Disorders Ctr, Dept Psychiat & Human Behav,Sleep Med, 5th Floor,211 South 9th St, Philadelphia, PA 19107 USAThomas Jefferson Univ, Sidney Kimmel Med Coll, Jefferson Sleep Disorders Ctr, Dept Psychiat & Human Behav,Sleep Med, 5th Floor,211 South 9th St, Philadelphia, PA 19107 USA
Doghramji, Karl
;
Jangro, William C.
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h-index: 0
机构:
Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Psychiat & Human Behav, Adult Residency Training Program, 833 Chestnut St,Suite 210, Philadelphia, PA 19107 USAThomas Jefferson Univ, Sidney Kimmel Med Coll, Jefferson Sleep Disorders Ctr, Dept Psychiat & Human Behav,Sleep Med, 5th Floor,211 South 9th St, Philadelphia, PA 19107 USA
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Enomoto, Tatsuya
;
Yamashita, Akira
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Yamashita, Akira
;
Torigoe, Kazuhiro
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Torigoe, Kazuhiro
;
Horiuchi, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Horiuchi, Hiroshi
;
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Hirayama, Shigeto
;
Nakahara, Kae
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Nakahara, Kae
;
Yanase, Makoto
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Yanase, Makoto
;
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机构:
Sakai, Hiroyasu
;
Ikegami, Daigo
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Ikegami, Daigo
;
Nagase, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Kitasato Univ, Sch Pharm, Dept Med Chem, Minato Ku, Tokyo 1088641, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Nagase, Hiroshi
;
Suzuki, Tsutomu
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Suzuki, Tsutomu
;
Iseki, Masako
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Iseki, Masako
;
Inada, Eiichi
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Inada, Eiichi
;
Narita, Minoru
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
机构:
Univ Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
Alsaadi, Saad M.
;
McAuley, James H.
论文数: 0引用数: 0
h-index: 0
机构:
Neurosci Res Australia, Sydney, NSW, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
McAuley, James H.
;
Hush, Julia M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Fac Hlth Sci, Sydney, NSW 2050, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
Hush, Julia M.
;
Maher, Chris G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, AustraliaUniv Sydney, George Inst Global Hlth, Musculoskeletal Div, Sydney, NSW 2050, Australia
机构:
Univ Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Alvarenga Dias, Rejane Camila
;
Kulak Junior, Jaime
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Kulak Junior, Jaime
;
Ferreira da Costa, Eloise Haydee
论文数: 0引用数: 0
h-index: 0
机构:
Evangel Mackenzie Univ, Dept Med, R Padre Agostinho 2770, BR-80730000 Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Ferreira da Costa, Eloise Haydee
;
Nisihara, Renato Mitsunori
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
Evangel Mackenzie Univ, Dept Med, R Padre Agostinho 2770, BR-80730000 Curitiba, Parana, Brazil
Positivo Univ, Dept Med, Curitiba, Parana, BrazilUniv Fed Parana, Post Grad Program Gynecol & Obstet, Curitiba, Parana, Brazil
机构:
Thomas Jefferson Univ, Sidney Kimmel Med Coll, Jefferson Sleep Disorders Ctr, Dept Psychiat & Human Behav,Sleep Med, 5th Floor,211 South 9th St, Philadelphia, PA 19107 USAThomas Jefferson Univ, Sidney Kimmel Med Coll, Jefferson Sleep Disorders Ctr, Dept Psychiat & Human Behav,Sleep Med, 5th Floor,211 South 9th St, Philadelphia, PA 19107 USA
Doghramji, Karl
;
Jangro, William C.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Psychiat & Human Behav, Adult Residency Training Program, 833 Chestnut St,Suite 210, Philadelphia, PA 19107 USAThomas Jefferson Univ, Sidney Kimmel Med Coll, Jefferson Sleep Disorders Ctr, Dept Psychiat & Human Behav,Sleep Med, 5th Floor,211 South 9th St, Philadelphia, PA 19107 USA
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Enomoto, Tatsuya
;
Yamashita, Akira
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Yamashita, Akira
;
Torigoe, Kazuhiro
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Torigoe, Kazuhiro
;
Horiuchi, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Horiuchi, Hiroshi
;
论文数: 引用数:
h-index:
机构:
Hirayama, Shigeto
;
Nakahara, Kae
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Nakahara, Kae
;
Yanase, Makoto
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Yanase, Makoto
;
论文数: 引用数:
h-index:
机构:
Sakai, Hiroyasu
;
Ikegami, Daigo
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Ikegami, Daigo
;
Nagase, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Kitasato Univ, Sch Pharm, Dept Med Chem, Minato Ku, Tokyo 1088641, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Nagase, Hiroshi
;
Suzuki, Tsutomu
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Suzuki, Tsutomu
;
Iseki, Masako
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Iseki, Masako
;
Inada, Eiichi
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Inada, Eiichi
;
Narita, Minoru
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan
Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Bunkyou Ku, Tokyo 1138421, JapanHoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428501, Japan