Staphylococcus aureusin Atopic Dermatitis: Past, Present, and Future

被引：14
作者：
Hwang, Jonwei [1 ]
Jaros, Joanna [2 ]
Shi, Vivian Y. [3 ]
机构：
[1] Univ Illinois, Coll Med, Chicago, IL USA
[2] AMITA St Joseph Transit Year Program, Chicago, IL USA
[3] Univ Arizona, Div Dermatol, Dept Med, 7165 N Pima Canyon Dr, Tucson, AZ 85718 USA
来源：
DERMATITIS | 2020年 / 31卷 / 04期
关键词：
RANDOMIZED PHASE-I; SKIN MICROBIOME; VITAMIN-D; ANTIMICROBIAL PEPTIDES; DISEASE SEVERITY; FUSIDIC ACID; COLONIZATION; VACCINE; CHILDREN; IMMUNOGENICITY;
D O I：
10.1097/DER.0000000000000589
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The role ofStaphylococcus aureus(SA) in the pathogenesis and management in atopic dermatitis is rapidly evolving. The modern understanding of SA in atopic dermatitis now includes an expanded array of virulence factors, the interplay of clonal and temporal shifts in SA populations, and host factors such as filaggrin and natural moisturizing factor. New, emerging therapies that focus on long-term, targeted elimination of SA colonization are currently under investigation (Br J Dermatol2017;17(1)63-71). Herein, we discuss and review the latest staphylococcal and microbiome-modifying therapies including topical antibiotics, topical natural oil fatty acids, anti-SA vaccines, microbial transplantation, vitamin D supplementation, dupilumab and proposed future investigative directions.
引用
收藏
页码：247 / 258
页数：12
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