Connective tissue growth factor (CTGF/CCN2) and Connexin-43 (Cx43) expression are upregulated in human adipose-derived stromal cells (hASCs) over the course of osteogenic differentiation

被引：0

作者：

Panetta, N. J. ^{[1
]}

Gupta, D. M. ^{[1
]}

Gupta, A. ^{[1
]}

Lee, J. K. ^{[1
]}

Commons, G. W. ^{[1
]}

Longaker, M. T. ^{[1
]}

机构：

[1] Stanford Univ, Stanford, CA 94305 USA

来源：

CRANIOFACIAL SURGERY 13: PROCEEDINGS OF THE THIRTEEN CONGRESS OF THE INTERNATIONAL SOCIETY OF CRANIOFACIAL SURGERY AND PARIS DISTRACTION SYMPOSIUM | 2009年

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中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Work is ongoing to shed light upon the role of mechanotransduction in the settings of skeletal development and bone healing. Of particular interest to our laboratory, harnessing an understanding of how externally applied forces may impact the differentiation of progenitor cells specifically hASCs in a pro-osteogenic fashion is of utmost importance. Possession of this knowledge will undoubtedly play a critical role in the development of cell-based skeletal tissue engineering strategies utilizing this multipotent progenitor population. As such, we have initiated a series of preliminary studies investigating the gene expression patterns of several proteins known to play a critical role in cell-cell communication in skeletal tissues over the course of osteogenic differentiation of hASCs.

引用

页码：171 / 173

页数：3