H(2)S (hydrogen sulfide) has recently been recognized as a signalling molecule as well as a cytoprotectant. We recently demonstrated that 3MST (3-mercaptopyruvate sulfurtransferase) produces H(2)S from 3MP (3-mercaptopyruvate). Although a reducing substance is required for an intermediate persulfide at the active site of 3MST to release H(2)S, the substance has not been identified. In the present study we show that Trx (thioredoxin) and DHLA (dihydrolipoic acid) associate with 3MST to release H(2)S. Other reducing substances, such as NADPH, NADH, GSH, cysteine and CoA, did not have any effect on the reaction. We also show that 3MST produces H(2)S from thiosulfate. The present study provides a new insight into a mechanism for the production of H(2)S by 3MST.
机构:
Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Sorrentino, Raffaella
;
论文数: 引用数:
h-index:
机构:
Maffia, Pasquale
;
论文数: 引用数:
h-index:
机构:
Mirone, Vincenzo
;
Imbimbo, Ciro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Imbimbo, Ciro
;
Fusco, Ferdinando
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Fusco, Ferdinando
;
De Palma, Raffaele
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples 2, Dept Expt Med, I-80100 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
De Palma, Raffaele
;
Ignarro, Louis J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Ignarro, Louis J.
;
Cirino, Giuseppe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
机构:
Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Sorrentino, Raffaella
;
论文数: 引用数:
h-index:
机构:
Maffia, Pasquale
;
论文数: 引用数:
h-index:
机构:
Mirone, Vincenzo
;
Imbimbo, Ciro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Imbimbo, Ciro
;
Fusco, Ferdinando
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Fusco, Ferdinando
;
De Palma, Raffaele
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples 2, Dept Expt Med, I-80100 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
De Palma, Raffaele
;
Ignarro, Louis J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
Ignarro, Louis J.
;
Cirino, Giuseppe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy
Univ Naples Federico II, Interdept Res Ctr Sexual Med, I-80131 Naples, ItalyUniv Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA