Peripheral platelet phagocytosis in an extremely low birth weight infant : a case report

被引：0
作者：
Hatanaka, Daisuke [1 ]
Ito, Kana [1 ,2 ]
Fukama, Eisuke [1 ]
Nomura, Tomoaki [1 ]
Kusakari, Michiko [1 ]
Takahashi, Hidehiro [1 ]
Nakamura, Toshihiko [1 ]
Takahashi, Naoto [3 ]
机构：
[1] Japanese Red Cross Musashino Hosp, Dept Neonatol, Tokyo, Japan
[2] Natl Def Med Coll Hosp, Dept Pediat, Saitama, Japan
[3] Univ Tokyo, Dept Pediat, Sch Med, Tokyo, Japan
来源：
FUKUSHIMA JOURNAL OF MEDICAL SCIENCE | 2022年 / 68卷 / 02期
关键词：
extremely low birth weight infant; sepsis; thrombocytopenia; platelet phagocytosis; cytokine profile; CYTOKINE PROFILE; PREMATURE-INFANT;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 768 g female neonate, born at 25 weeks' gestation, developed sepsis due to methicillin-resistant Staphylococcus epidermidis on day 14. Severe thrombocytopenia was observed, and hemophagocytic macrophages were identified in her peripheral blood smear. Cytokine profiles at the time of onset suggested that an inflammatory cytokine storm had activated lymphocytes and macrophages, leading to platelet phagocytosis. After administration of vancomycin for 14 days and immunoglobulin therapy, she improved without any complications. Considering the results of cytokine profiles, early intervention for infection may have prevented progression to hemophagocytic lymphohistiocytosis and reduced the severity of clinical symptoms.
引用
收藏
页码：129 / 134
页数：6
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