Cancer stem cells - Models, mechanisms and implications for improved treatment

被引：79
作者：
Zhou, Jiangbing [1 ]
Zhang, Ying [1 ]
机构：
[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA
来源：
CELL CYCLE | 2008年 / 7卷 / 10期
关键词：
cancer stem cells; surface marker; side population; sphere culture; signaling pathway; ABC transporter; cancer therapy;
D O I：
10.4161/cc.7.10.5953
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cancer stem cell research has drawn a lot of attention recently. The importance of cancer stem cell research lies in the possibility of providing new approaches for improved understanding of cancer biology and cancer treatment. However, cancer stem cell research is still at its infancy. In this review, we will discuss the concept of cancer stem cells and the commonly used approaches for isolating or enriching cancer stem cells. We then review the common features of cancer stem cells including resistance to cancer drugs and stresses such as hypoxia and radiation. We also summarize signaling pathways which might be preferentially important for cancer stem cells. Finally, we will propose a new Yin-Yang model of cancer stem cells and discuss the possibility of developing new drugs that target cancer stem cells for improved treatment of cancer.
引用
收藏
页码：1360 / 1370
页数：11
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