In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells

被引：42
|
作者：
Skupien, Katarzyna [2 ]
Kostrzewa-Nowak, Dorota [1 ]
Oszmianski, Jan [3 ]
Tarasiuk, Jolanta [1 ]
机构：
[1] Univ Szczecin, Dept Biochem, PL-71412 Szczecin, Poland
[2] Acad Agr Szczecin, Dept Proc & Storage Plant Raw Mat, PL-71434 Szczecin, Poland
[3] Univ Agr, Dept Fruit Vegetable & Cereal Technol, PL-50375 Wroclaw, Poland
来源：
PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 05期
关键词：
berry plants; leaf extracts; phenolic compounds; human promyelocytic HL60 cells; multidrug resistance MDR; in vitro antileukaemic activity;
D O I：
10.1002/ptr.2411
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of the present study was to determine in vitro antileukaemic activities of extracts obtained from chokeberry (Aronia melanocarpa [Michx] Elliot) and mulberry (Morus alba L.) leaves against promyelocytic HL60 cell line and its multidrug resistant sublines exhibiting two different MDR phenotypes: HL60/ VINC (overexpressing P-glycoprotein) and HL60/DOX (overexpressing MRP1 protein). It was found that the extracts from chokeberry and mulberry leaves were active against the sensitive leukaemic cell line HL60 and retained the in vitro activity against multidrug resistant sublines (HL60/VINC and HL60/DOX). The values of resistance factor (RF) found for these extracts were very low lying in the range 1.2-1.6. Copyright (C) 2008 John Wiley & Sons, Ltd.
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页码：689 / 694
页数：6
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