Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

被引：21
作者：
Klimara, Miles J. [1 ]
Randall, Derrick R. [2 ]
Allen, Jacqueline [3 ]
Figueredo, Edgar [4 ]
Johnston, Nikki [5 ,6 ]
机构：
[1] Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 200 Hawkins Dr, Iowa City, IA 52242 USA
[2] Univ Calgary, Sect Otolaryngol Head & Neck Surg, Dept Surg, Calgary, AB, Canada
[3] Univ Auckland, Dept Otolaryngol Head & Neck Surg, Auckland, New Zealand
[4] Univ Washington, Dept Surg, Minimally Invas Surg, Surg Crit Care,Seattle VA Med Ctr, Seattle, WA 98195 USA
[5] Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA
[6] Med Coll Wisconsin, Dept Microbiol & Immunol, Milwaukee, WI 53226 USA
来源：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2020年 / 1481卷 / 01期
关键词：
reflux; airway; laryngopharyngeal reflux (LPR); extraesophageal reflux (EER); pepsin; cough; MAGNETIC SPHINCTER AUGMENTATION; PLACEBO-CONTROLLED TRIAL; LAPAROSCOPIC ANTIREFLUX SURGERY; CHRONIC THROAT SYMPTOMS; PUMP INHIBITOR THERAPY; GASTROESOPHAGEAL-REFLUX; LARYNGOPHARYNGEAL REFLUX; CHRONIC COUGH; DOUBLE-BLIND; EXTRAESOPHAGEAL REFLUX;
D O I：
10.1111/nyas.14366
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux-associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.
引用
收藏
页码：127 / 138
页数：12
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