Microbial transformation of pyrethrosin

被引：12
作者：
Galal, AM [1 ]
机构：
[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 08期
关键词：
D O I：
10.1021/np0100082
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Microbial transformation of the germacranolide pyrethrosin (1) using Rhizopus nigricans NRRL 1477 has resulted in the isolation of 6 alpha -acetoxy-1 beta ,4 alpha -dihydroxy-5,7 alphaH,8 betaH-eudesm-11 beta ,13-dihydro-8,12-olide (5), a new eudesmanolide-type metabolite, in addition to the previously reported eudesmanolides: 2, 3, 4, and 6. The structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses. The isolated metabolites exhibited cytotoxic, antifungal, and antiprotozoal activities.
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页码：1098 / 1099
页数：2
相关论文
共 14 条
  • [1] CHROMOSOMAL-ABERRATIONS CAUSED BY SESQUITERPENE LACTONES IN CHINESE-HAMSTER OVARY CELLS
    ABEYSEKERA, BF
    ABRAMOWSKI, Z
    TOWERS, GHN
    [J]. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 1985, 13 (03) : 365 - 369
  • [2] Abourashed EA, 1999, CURR MED CHEM, V6, P359
  • [3] SESQUITERPENOIDS .8. THE CONSTITUTION OF PYRETHROSIN
    BARTON, DHR
    DEMAYO, P
    [J]. JOURNAL OF THE CHEMICAL SOCIETY, 1957, (JAN): : 150 - 158
  • [4] COMPARISONS OF 2-INVITRO CYTO-TOXICITY ASSAYS - THE NEUTRAL RED (NR) AND TETRAZOLIUM MTT TESTS
    BORENFREUND, E
    BABICH, H
    MARTINALGUACIL, N
    [J]. TOXICOLOGY IN VITRO, 1988, 2 (01) : 1 - 6
  • [5] REVISION OF THE STRUCTURE OF AN EUDESMANOLIDE ISOLATED FROM LASIOLAENA-SANTOSII
    CARDONA, ML
    FERNANDEZ, I
    GARCIA, B
    PEDRO, JR
    [J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (04): : 1042 - 1045
  • [6] SESQUITERPENE LACTONES FROM PYRETHRUM FLOWERS
    DOSKOTCH, RW
    ELFERALY, FS
    HUFFORD, CD
    [J]. CANADIAN JOURNAL OF CHEMISTRY, 1971, 49 (12): : 2103 - &
  • [7] ElSayed KA, 1996, J NAT TOXINS, V5, P261
  • [8] Microbial transformation of parthenolide
    Galal, AM
    Ibrahim, ARS
    Mossa, JS
    El-Feraly, FS
    [J]. PHYTOCHEMISTRY, 1999, 51 (06) : 761 - 765
  • [9] IINO Y, 1972, AGR BIOL CBGEM, P2505
  • [10] IRIUCHIJIMA S, 1970, AGR BIOL CHEM TOKYO, P204
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