PI(4,5)P2 regulation of surface membrane traffic

被引：311
作者：
Martin, TFJ [1 ]
机构：
[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 04期
关键词：
D O I：
10.1016/S0955-0674(00)00241-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phosphatidylinositol 4,5-biphosphate (PI[4,5]P-2) has emerged as an important signaling molecule in the membrane for regulating vesicle exo- and endocytosis and the accompanying actin cytoskeletal rearrangements. Localization studies with GFP-tagged binding domains and antibodies provide new views of the non-uniform, dynamic distribution of PI(4,5)P-2 in membranes and its organization in raft-like domains. The targeting of phosphoinositide kinases by GTPases can coordinate the reactions of membrane fusion and fission with cytoskeletal assembly, providing a basis for membrane movement.
引用
收藏
页码：493 / 499
页数：7
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