Gene therapy for heart failure: time to go back to the drawing board

被引:2
作者
Greenberg, Barry [1 ]
机构
[1] Univ Calif San Diego, La Jolla, CA 92093 USA
关键词
CALCIUM UP-REGULATION; SARCOPLASMIC-RETICULUM CA2+-ATPASE; CLINICAL-TRIAL; DISEASE; MODEL; EXPRESSION; SERCA2A; VECTORS; DESIGN;
D O I
10.1002/ejhf.914
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This article refers to 'Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial', by J.-S. Hulot et al., published in this issue on pages 1534-1541.
引用
收藏
页码:1542 / 1544
页数:3
相关论文
共 22 条
  • [1] Calcium cycling and signaling in cardiac myocytes
    Bers, Donald M.
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2008, 70 : 23 - 49
  • [2] Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a
    del Monte, F
    Harding, SE
    Schmidt, U
    Matsui, T
    Kang, ZB
    Dec, W
    Gwathmey, JK
    Rosenzweig, A
    Hajjar, RJ
    [J]. CIRCULATION, 1999, 100 (23) : 2308 - 2311
  • [3] Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2+-ATPase in a rat model of heart failure
    del Monte, F
    Williams, E
    Lebeche, D
    Schmidt, U
    Rosenzweig, A
    Gwathmey, JK
    Lewandowski, ED
    Hajjar, RJ
    [J]. CIRCULATION, 2001, 104 (12) : 1424 - 1429
  • [4] Impact of AAV Capsid-Specific T-Cell Responses on Design and Outcome of Clinical Gene Transfer Trials with Recombinant Adeno-Associated Viral Vectors: An Evolving Controversy
    Ertl, Hildegund C. J.
    High, Katherine A.
    [J]. HUMAN GENE THERAPY, 2017, 28 (04) : 328 - 337
  • [5] Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure
    Greenberg, B.
    Butler, J.
    Felker, G. M.
    Ponikowski, P.
    Voors, A. A.
    Pogoda, J. M.
    Provost, R.
    Guerrero, J.
    Hajjar, R. J.
    Zsebo, K. M.
    [J]. GENE THERAPY, 2016, 23 (03) : 313 - 319
  • [6] Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial
    Greenberg, Barry
    Butler, Javed
    Felker, G. Michael
    Ponikowski, Piotr
    Voors, Adriaan A.
    Desai, Akshay S.
    Barnard, Denise
    Bouchard, Alain
    Jaski, Brian
    Lyon, Alexander R.
    Pogoda, Janice M.
    Rudy, Jeffrey J.
    Zsebo, Krisztina M.
    [J]. LANCET, 2016, 387 (10024) : 1178 - 1186
  • [7] Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure The CUPID 2 Trial (Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b)
    Greenberg, Barry
    Yaroshinsky, Alex
    Zsebo, Krisztina M.
    Butler, Javed
    Felker, G. Michael
    Voors, Adriaan A.
    Rudy, Jeffrey J.
    Wagner, Kim
    Hajjar, Roger J.
    [J]. JACC-HEART FAILURE, 2014, 2 (01) : 84 - 92
  • [8] ABNORMAL INTRACELLULAR CALCIUM HANDLING IN MYOCARDIUM FROM PATIENTS WITH END-STAGE HEART-FAILURE
    GWATHMEY, JK
    COPELAS, L
    MACKINNON, R
    SCHOEN, FJ
    FELDMAN, MD
    GROSSMAN, W
    MORGAN, JP
    [J]. CIRCULATION RESEARCH, 1987, 61 (01) : 70 - 76
  • [9] Adeno-associated virus-mediated gene therapy in cardiovascular disease
    Hammoudi, Nadjib
    Ishikawa, Kiyotake
    Hajjar, Roger J.
    [J]. CURRENT OPINION IN CARDIOLOGY, 2015, 30 (03) : 228 - 234
  • [10] Calcium cycling in congestive heart failure
    Hasenfuss, G
    Pieske, B
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (08) : 951 - 969