In Vivo Spreading of Tau Pathology

被引：21

作者：

Soto, Claudio ^{[1
]}

机构：

[1] Univ Texas Houston, Dept Neurol, Sch Med, Mitchell Ctr Alzheimers Dis & Related Brain Disor, Houston, TX 77030 USA

来源：

NEURON | 2012年 / 73卷 / 04期

关键词：

NEURODEGENERATIVE-DISEASES; TRANSMISSION;

D O I：

10.1016/j.neuron.2012.02.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent findings have suggested that tau pathology may spread in the brain by a prion-like mechanism. In this issue of Neuron, de Calignon et al. (2012) recreated an early stage of neurofibrillary tangle pathology to show that tau aggregates initially generated in a circumscribed area spread throughout the brain and lead to neurodegeneration.

引用

页码：621 / 623

页数：3

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