Synthesis and Cytotoxic Activity of 1,3,5-Triazinane Derivatives Based on Primary Amines and Amino Acids Esters

被引：0

作者：

Kireeva, D. R. ^{[1
]}

Sadretdinov, S. S. ^{[1
]}

Musina, A., I ^{[1
]}

Ishmetova, D., V ^{[2
]}

Vakhitov, V. A. ^{[2
]}

Murinov, Yu, I ^{[1
]}

Dokichev, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, Ufa 450054, Russia

[2] Russian Acad Sci, Inst Biochem & Genet, Ufa Sci Ctr, Ufa 450054, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2022年 / 92卷 / 01期

关键词：

1; 3; 5-triazinane; cytotoxic activity; amino acid; cyclocondensation;

D O I：

10.1134/S1070363222010054

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 1,3,5-triazinane derivatives was synthesized and their cytotoxic activity was studied in vitro on normal cell line (HEK293) and tumor cell lines (SH-SY5Y, MCF-7, A549). It was shown that the studied compounds have moderate cytotoxic activity against normal and tumor cell lines.

引用

页码：24 / 28

页数：5

共 42 条

[41] Regio- and stereoselective 1,3-dipolar cycloaddition of azomethine ylides based on isatins and (thia)proline to 3-nitro-2-(trifluoro(trichloro)methyl)-2H-chromenes: synthesis and cytotoxic activity of 6-(trihalomethyl)-spiro[chromeno(thia)pyrrolizidine-11,3′-indolin]-2′-ones
Kutyashev, Igor B.
Ulitko, Maria, V
Barkov, Alexey Yu
Zimnitskiy, Nikolay S.
Korotaev, Vladislav Yu
Sosnovskikh, Vyacheslav Ya
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2021, 57 (7-8) : 751 - 763
[42] Regio- and Stereoselective 1,3-dipolar Cycloaddition of Azomethine Ylides Based on Isatins and (thia)proline to 3-nitro-2-(trifluoro(trichloro)methyl)-2H-chromenes: Synthesis and Cytotoxic Activity of 6-(trihalomethyl)-spiro[chromeno(thia)pyrrolizidine-11,3'-indolin]-2'-ones
Igor B. Kutyashev
Maria V. Ulitko
Alexey Yu. Barkov
Nikolay S. Zimnitskiy
Vladislav Yu. Korotaev
Vyacheslav Ya. Sosnovskikh
Chemistry of Heterocyclic Compounds, 2021, 57 : 751 - 763

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