The effect of combined inhibition of C5aR1 and CD14 on phagocytosis of E. coli in human whole blood

被引:0
|
作者
Christiansen, Dorte [1 ,2 ]
Skjeflo, Espen Waage [1 ,2 ]
Landsem, Anne [1 ,2 ,3 ]
Mathisen, Monica Dammen [1 ,2 ]
Fure, Hilde [1 ,2 ]
Stenvik, Jorgen [4 ]
Woodruff, Trent [5 ]
Espevik, Terje [4 ]
Mollnes, Tom Eirik [1 ,2 ,3 ,4 ,6 ,7 ]
机构
[1] Nordland Hosp, Res Lab, Bodo, Norway
[2] Nordland Hosp, Dept Lab Med, Bodo, Norway
[3] Univ Tromso, Inst Clin Med, N-9001 Tromso, Norway
[4] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, Trondheim, Norway
[5] Univ Queensland, Sch Biomed Sci, Fac Med & Biomed Sci, Brisbane, Qld, Australia
[6] Natl Hosp Norway, Dept Immunol, Oslo Univ Hosp, Oslo, Norway
[7] Univ Oslo, N-0316 Oslo, Norway
关键词
D O I
10.1016/j.imbio.2016.06.212
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
197
引用
收藏
页码:1220 / 1220
页数:1
相关论文
共 50 条
  • [21] The role of iC3b opsonization, C5a receptor and CD14 in E-coli-induced upregulation of leukocyte CD11b (CR3), phagocytosis and oxidative burst in human whole blood
    Christiansen, D
    Brekke, OL
    Fure, H
    Fung, M
    Mollnes, TE
    MOLECULAR IMMUNOLOGY, 2004, 41 (2-3) : 221 - 222
  • [22] Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood
    Nymo, Stig
    Gustavsen, Alice
    Nilsson, Per H.
    Lau, Corinna
    Espevik, Terje
    Mollnes, Tom Eirik
    JOURNAL OF IMMUNOLOGY, 2016, 196 (05): : 2293 - 2299
  • [23] Selective inhibition of TNF-α and IL-1β do not affect E-coli-induced inflammation in human whole blood, in contrast to combined complement- and CD14-inhibition
    Barratt-Due, Andreas
    Thorgersen, Ebbe B.
    Lindstad, Julie
    Pharo, Anne
    Brekke, Ole-Lars
    Christiansen, Dorte
    Lambris, John D.
    Mollnes, Tom E.
    MOLECULAR IMMUNOLOGY, 2009, 46 (14) : 2838 - 2838
  • [24] Combined inhibition of complement (C5) and CD14 markedly attenuates blood thrombogenicity, inflammation and hemodynamic changes in porcine sepsis
    Barratt-Duel, Andreas
    Thorgersen, Ebbe Billmann
    Egge, Kjetil
    Pischke, Soren
    Sokolov, Andrey
    Hellerud, Bernt Christian
    Lindstad, Julie Katrine
    Pharo, Anne
    Nunn, Miles
    Scott, Helge
    Mollnes, Tom Eirik
    IMMUNOBIOLOGY, 2012, 217 (11) : 1152 - 1152
  • [25] Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model
    Bjerkhaug, Aline U.
    Granslo, Hildegunn N.
    Cavanagh, Jorunn Pauline
    Hoiland, Ina
    Ludviksen, Judith Krey
    Lau, Corinna
    Espevik, Terje
    Mollnes, Tom Eirik
    Klingenberg, Claus
    PEDIATRIC RESEARCH, 2023, 94 (02) : 512 - 519
  • [26] Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model
    Aline U. Bjerkhaug
    Hildegunn N. Granslo
    Jorunn Pauline Cavanagh
    Ina Høiland
    Judith Krey Ludviksen
    Corinna Lau
    Terje Espevik
    Tom Eirik Mollnes
    Claus Klingenberg
    Pediatric Research, 2023, 94 : 512 - 519
  • [27] An ex vivo posttreatment model of sepsis: Effect on inflammation by adding complement- and CD14-inhibitors after E. coli to human whole blood
    Egge, Kjetil H.
    Thorgersen, Egge B.
    Lindstad, Julie K.
    Pharo, Anne M.
    Barratt-Due, Andreas
    Mollnes, Tom E.
    IMMUNOBIOLOGY, 2012, 217 (11) : 1137 - 1138
  • [28] C5 has no effect on normal physiological hemostasis but is essential for E. coli-induced coagulation activation in human whole blood
    Landsem, Anne
    Fure, Hilde
    Ludviksen, Judith Krey
    Lappegard, Knut Tore
    Mollnes, Tom Eirik
    Brekke, Ole-Lars
    MOLECULAR IMMUNOLOGY, 2015, 67 (01) : 155 - 155
  • [29] Key role of CD14 in the E. coli- and LPS-induced mRNA down regulation of the C5a receptors CD88 and C5L2
    Fure, H.
    Brekke, O. L.
    Lambris, J. D.
    Mollnes, T. E.
    MOLECULAR IMMUNOLOGY, 2010, 47 (13) : 2241 - 2241
  • [30] The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human
    Brekke, Ole-Lars
    Christiansen, Dorte
    Fure, Hilde
    Fung, Michael
    Mollnes, Tom E.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (06) : 1404 - 1413