Neural stem cells: balancing self-renewal with differentiation

被引：310
作者：
Doe, Chris Q. [1 ]
机构：
[1] Univ Oregon, Inst Mol Biol, Inst Neurosci, Howard Hughes Med Inst, Eugene, OR 97403 USA
来源：
DEVELOPMENT | 2008年 / 135卷 / 09期
关键词：
D O I：
10.1242/dev.014977
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stem cells are captivating because they have the potential to make multiple cell types yet maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation and have revealed the proteins, processes and pathways that all converge to regulate neural progenitor self-renewal. If we can better understand how stem cells balance self-renewal versus differentiation, we will significantly advance our knowledge of embryogenesis, cancer biology and brain evolution, as well as the use of stem cells for therapeutic purposes.
引用
收藏
页码：1575 / 1587
页数：13
相关论文
共 157 条
[1]   A general role of hedgehog in the regulation of proliferation [J].
Agathocleous, Michalis ;
Locker, Morgane ;
Harris, William A. ;
Perron, Muriel .
CELL CYCLE, 2007, 6 (02) :156-159
[2]   In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog [J].
Ahn, S ;
Joyner, AL .
NATURE, 2005, 437 (7060) :894-897
[3]   Regulation of post-embryonic neuroblasts by Drosophila Grainyhead [J].
Almeida, MS ;
Bray, SJ .
MECHANISMS OF DEVELOPMENT, 2005, 122 (12) :1282-1293
[4]   Hedgehog antagonist RENKCTD11 regulates proliferation and apoptosis of developing granule cell progenitors [J].
Argenti, B ;
Gallo, R ;
Di Marcotullio, L ;
Ferretti, E ;
Napolitano, M ;
Canterini, S ;
De Smaele, E ;
Greco, A ;
Fiorenza, MT ;
Maroder, M ;
Screpanti, I ;
Alesse, E ;
Gulino, A .
JOURNAL OF NEUROSCIENCE, 2005, 25 (36) :8338-8346
[5]  
ARTAVANISTSAKONAS S, 1991, ANNU REV CELL BIOL, V7, P427
[6]   Worniu, a snail family zinc-finger protein, is required for brain development in Drosophila [J].
Ashraf, SI ;
Ganguly, A ;
Roote, J ;
Ip, YT .
DEVELOPMENTAL DYNAMICS, 2004, 231 (02) :379-386
[7]  
Ashraf SI, 2001, DEVELOPMENT, V128, P4757
[8]   REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis [J].
Ballas, N ;
Grunseich, C ;
Lu, DD ;
Speh, JC ;
Mandel, G .
CELL, 2005, 121 (04) :645-657
[9]   The many faces of REST oversee epigenetic programming of neuronal genes [J].
Ballas, N ;
Mandel, G .
CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (05) :500-506
[10]   The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila [J].
Bello, Bruno ;
Reichert, Heinrich ;
Hirth, Frank .
DEVELOPMENT, 2006, 133 (14) :2639-2648
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