Gut Microbiota and Alimentary Tract Injury

被引：6

作者：

Chen, Ye ^{[1
]}

Wu, Guangyan ^{[2
]}

Zhao, Yongzhong ^{[3
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, Guangzhou, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Guangzhou, Peoples R China

[3] Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44106 USA

来源：

GUT MICROBIOTA AND PATHOGENESIS OF ORGAN INJURY | 2020年 / 1238卷

关键词：

Microbiota; Microbiome; Chronic gastritis; Gastric cancer; Inflammatory bowel disease; Irritable bowel syndrome; Colorectal cancer; Dysbiosis; IRRITABLE-BOWEL-SYNDROME; LOW FODMAP DIET; FECAL MICROBIOTA; INTESTINAL MICROBIOTA; HELICOBACTER-PYLORI; ULCERATIVE-COLITIS; CROHNS-DISEASE; PROBIOTICS; TRANSPLANTATION; MODULATION;

D O I：

10.1007/978-981-15-2385-4_2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gastrointestinal (GI) tract is inhabited by a diverse array of microbes, which play crucial roles in health and disease. Dysbiosis of microbiota has been tightly linked to gastrointestinal inflammatory and malignant diseases. Here we highlight the role of Helicobacter pylori alongside gastric microbiota associated with gastric inflammation and cancer. We summarize the taxonomic and functional aspects of intestinal microbiota linked to inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and colorectal cancer in clinical investigations. We also discuss microbiome-related animal models. Nevertheless, there are tremendous opportunities to reveal the causality of microbiota in health and disease and detailed microbe-host interaction mechanisms by which how dysbiosis is causally linked to inflammatory disease and cancer, in turn, potentializing clinical interventions with a personalized high efficacy.

引用

页码：11 / 22

页数：12

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